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- NCIT_C102758 IAO_0000115 "Autologous T-lymphocytes transduced with a modified lentiviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment) and the zeta chain of the TCR/CD3 complex (CD3-zeta), coupled to the signaling domain of 4-1BB (CD137), with potential immunomodulating and antineoplastic activities. Upon transfusion, tisagenlecleucel directs the T-lymphocytes to CD19-expressing tumor cells, thereby inducing a selective toxicity in CD19-expressing tumor cells. The 4-1BB co-stimulatory molecule signaling domain enhances activation and signaling after recognition of CD19 and the inclusion of this signaling domain may increase the antitumor activity compared to the inclusion of the CD3-zeta chain alone. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. CD3-zeta (or CD247) is a transmembrane signaling adaptor polypeptide that regulates the assembly of complete TCR complexes and their expression on the cell surface." @default.
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- NCIT_C102758 NCIT_P107 "Tisagenlecleucel" @default.
- NCIT_C102758 NCIT_P108 "Tisagenlecleucel" @default.
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- NCIT_C102758 NCIT_P210 "1823078-37-0" @default.
- NCIT_C102758 NCIT_P302 "B-cell precursor acute lymphoblastic leukemia (ALL) that is refractory or in second or later relapse; relapsed or refractory large B-cell lymphoma, including diffuse large B-cell lymphoma (DLBCL) and high grade B-cell lymphoma and DLBCL arising from follicular lymphoma" @default.
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- NCIT_C102758 NCIT_P329 "736184" @default.
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- NCIT_C102758 NCIT_P375 "Tisagenlecleucel" @default.
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- NCIT_C102758 hasExactSynonym "CART-19" @default.
- NCIT_C102758 hasExactSynonym "CART19" @default.
- NCIT_C102758 hasExactSynonym "CTL019 T-cells" @default.
- NCIT_C102758 hasExactSynonym "CTL019" @default.
- NCIT_C102758 hasExactSynonym "Kymriah" @default.
- NCIT_C102758 hasExactSynonym "TISAGENLECLEUCEL" @default.
- NCIT_C102758 hasExactSynonym "Tisagenlecleucel" @default.
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