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- NCIT_C102785 IAO_0000115 "A radioimmunoconjugate composed of the F(ab')2 fragment of human monoclonal antibody PGN650 against phosphatidylserine (PS) labeled with the radioisotope iodine I 124, with potential imaging activity upon positron-emission tomography (PET). Upon administration, the MoAb moiety of PGN650 binds to exposed PS on tumor cells, thereby allowing for the visualization of tumors upon PET. This may facilitate the assessment of the effectiveness of antitumor agents. The phospholipid PS is normally located on the inner leaflet of the plasma membrane of healthy cells but is flipped to the outer leaflet in the endothelial lining of the tumor vasculature and other tumor cells in response to chemo- or radio- treatments in addition to oxidative stress." @default.
- NCIT_C102785 NCIT_NHC0 "C102785" @default.
- NCIT_C102785 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C102785 NCIT_P106 "Indicator, Reagent, or Diagnostic Aid" @default.
- NCIT_C102785 NCIT_P108 "Iodine I 124 Anti-phosphatidylserine Monoclonal Antibody PGN650" @default.
- NCIT_C102785 NCIT_P208 "CL437023" @default.
- NCIT_C102785 NCIT_P329 "736553" @default.
- NCIT_C102785 NCIT_P330 "736553" @default.
- NCIT_C102785 NCIT_P399 "736553" @default.
- NCIT_C102785 normalizedInformationContent "100" @default.
- NCIT_C102785 referenceCount "1" @default.
- NCIT_C102785 hasExactSynonym "I-124 Anti-PS MoAb PNG650" @default.
- NCIT_C102785 hasExactSynonym "I-124 PGN650" @default.
- NCIT_C102785 hasExactSynonym "Iodine I 124 Anti-phosphatidylserine Monoclonal Antibody PGN650" @default.
- NCIT_C102785 inSubset NCIT_C176424 @default.
- NCIT_C102785 type Class @default.
- NCIT_C102785 isDefinedBy ncit.owl @default.
- NCIT_C102785 label "Iodine I 124 Anti-phosphatidylserine Monoclonal Antibody PGN650" @default.
- NCIT_C102785 subClassOf NCIT_C102785 @default.
- NCIT_C102785 subClassOf NCIT_C1446 @default.
- NCIT_C102785 subClassOf NCIT_C1511 @default.
- NCIT_C102785 subClassOf NCIT_C1512 @default.
- NCIT_C102785 subClassOf NCIT_C1908 @default.
- NCIT_C102785 subClassOf NCIT_C1909 @default.
- NCIT_C102785 subClassOf NCIT_C2124 @default.
- NCIT_C102785 subClassOf NCIT_C307 @default.
- NCIT_C102785 subClassOf NCIT_C308 @default.