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- NCIT_C102786 IAO_0000115 "A synthetic, glycomimetic molecule and pan-selectin antagonist, with potential use in a vaso-occlusive crisis. Upon administration, rivipansel prevents the interaction between leukocytes and the endothelium and may prevent cell activation and adhesion. By preventing selectin-mediated cell adhesion in sickle cell anemia, this agent may inhibit red blood cell-white blood cell interactions, normalize blood flow and reduce inflammation and vascular occlusive pain. GMI-1070 has the strongest antagonistic activity towards E-selectin but a sulfate-binding domain allows for interactions with P- and L-selectins. Selectins, containing lectin- and EGF-like domains, are a family of cell adhesion molecules implicated in inflammatory processes and cancer." @default.
- NCIT_C102786 NCIT_NHC0 "C102786" @default.
- NCIT_C102786 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C102786 NCIT_P107 "Rivipansel" @default.
- NCIT_C102786 NCIT_P108 "Rivipansel" @default.
- NCIT_C102786 NCIT_P208 "CL777451" @default.
- NCIT_C102786 NCIT_P210 "927881-99-0" @default.
- NCIT_C102786 NCIT_P319 "4B115V09LB" @default.
- NCIT_C102786 NCIT_P322 "CTRP" @default.
- NCIT_C102786 NCIT_P322 "FDA" @default.
- NCIT_C102786 NCIT_P329 "736621" @default.
- NCIT_C102786 NCIT_P330 "736621" @default.
- NCIT_C102786 NCIT_P399 "736621" @default.
- NCIT_C102786 normalizedInformationContent "100" @default.
- NCIT_C102786 referenceCount "1" @default.
- NCIT_C102786 hasExactSynonym "GMI-1070" @default.
- NCIT_C102786 hasExactSynonym "PF-06460031" @default.
- NCIT_C102786 hasExactSynonym "RIVIPANSEL" @default.
- NCIT_C102786 hasExactSynonym "Rivipansel" @default.
- NCIT_C102786 inSubset NCIT_C116977 @default.
- NCIT_C102786 inSubset NCIT_C116978 @default.
- NCIT_C102786 inSubset NCIT_C176424 @default.
- NCIT_C102786 inSubset NCIT_C63923 @default.
- NCIT_C102786 type Class @default.
- NCIT_C102786 isDefinedBy ncit.owl @default.
- NCIT_C102786 label "Rivipansel" @default.
- NCIT_C102786 subClassOf NCIT_C102786 @default.
- NCIT_C102786 subClassOf NCIT_C1908 @default.
- NCIT_C102786 subClassOf NCIT_C1909 @default.
- NCIT_C102786 subClassOf NCIT_C78275 @default.