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- NCIT_C102978 IAO_0000115 "A cell based cancer vaccine composed of mature polarized dendritic cells (DCs) and pulsed with apoptotic autologous tumor cells that has potential immunostimulating and antineoplatic activities. Dendritic cells (DCs) were treated with interleukin-1beta, tumor necrosis factor alpha, interferon-alpha (IFN-a), IFN-gamma and polyinosinic:polycytidylic acid (p-I:C) to produce mature alpha type-1 polarized DCs (alphaDC1) that are capable of producing high levels of interleukin-12p70 (IL-12p70). The alphaDC1 are subsequently pulsed with apoptotic autologous tumor cells. Upon administration, these DCs are able to induce a potent cytotoxic T lymphocyte (CTL) response against tumor associated antigens (TAAs), resulting in tumor cell lysis and inhibition of tumor cell growth. Apoptotic tumor cells contain an array of TAAs." @default.
- NCIT_C102978 NCIT_NHC0 "C102978" @default.
- NCIT_C102978 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C102978 NCIT_P108 "Apoptotic Autologous Tumor Cells-pulsed Alpha-type-1 Polarized Dendritic Cells" @default.
- NCIT_C102978 NCIT_P208 "CL437216" @default.
- NCIT_C102978 NCIT_P329 "739744" @default.
- NCIT_C102978 NCIT_P330 "739744" @default.
- NCIT_C102978 NCIT_P399 "739744" @default.
- NCIT_C102978 normalizedInformationContent "100" @default.
- NCIT_C102978 referenceCount "1" @default.
- NCIT_C102978 hasExactSynonym "Apoptotic Autologous Tumor Cells-pulsed Alpha-type-1 Polarized Dendritic Cells" @default.
- NCIT_C102978 inSubset NCIT_C128784 @default.
- NCIT_C102978 inSubset NCIT_C176424 @default.
- NCIT_C102978 type Class @default.
- NCIT_C102978 isDefinedBy ncit.owl @default.
- NCIT_C102978 label "Apoptotic Autologous Tumor Cells-pulsed Alpha-type-1 Polarized Dendritic Cells" @default.
- NCIT_C102978 subClassOf NCIT_C102978 @default.
- NCIT_C102978 subClassOf NCIT_C129820 @default.
- NCIT_C102978 subClassOf NCIT_C129821 @default.
- NCIT_C102978 subClassOf NCIT_C129826 @default.
- NCIT_C102978 subClassOf NCIT_C142078 @default.
- NCIT_C102978 subClassOf NCIT_C1663 @default.
- NCIT_C102978 subClassOf NCIT_C1908 @default.
- NCIT_C102978 subClassOf NCIT_C1909 @default.
- NCIT_C102978 subClassOf NCIT_C274 @default.
- NCIT_C102978 subClassOf NCIT_C28308 @default.
- NCIT_C102978 subClassOf NCIT_C28310 @default.
- NCIT_C102978 subClassOf NCIT_C307 @default.
- NCIT_C102978 subClassOf NCIT_C308 @default.
- NCIT_C102978 subClassOf NCIT_C923 @default.