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- NCIT_C103193 IAO_0000115 "A synthetic 14-amino acid peptide derived from a novel human peptide hormone, Tumor-Cells Apoptosis Factor (TCApF), with potential antineoplastic activity. Upon intravenous administration, tumor-cells apoptosis factor hormone-peptide binds to the T1/ST2 receptor (IL1RL1) and activates both caspase 8 and Bcl-2 mediated apoptosis, in addition to the activation of p38 MAPK and JNK signaling cascades in tumor cells. Furthermore, this agent inhibits angiogenesis by suppressing the expressions of vascular endothelial growth factor A (VEGFA) and fms-related tyrosine kinase 1 (VEGFR1). Tumor-cells apoptosis factor hormone-peptide also modulates immune system responses via increasing the expressions of interleukin-10 and anti-angiogenic interleukin. T1/ST2 receptor, a member of the toll/interleukin-1 receptor superfamily, is overexpressed in certain cancer cells." @default.
- NCIT_C103193 NCIT_A7 NCIT_C106011 @default.
- NCIT_C103193 NCIT_NHC0 "C103193" @default.
- NCIT_C103193 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C103193 NCIT_P107 "Tumor-Cells Apoptosis Factor Hormone-Peptide" @default.
- NCIT_C103193 NCIT_P108 "Tumor-Cells Apoptosis Factor Hormone-Peptide" @default.
- NCIT_C103193 NCIT_P207 "C2974969" @default.
- NCIT_C103193 NCIT_P210 "2120397-85-3" @default.
- NCIT_C103193 NCIT_P319 "SR717JCM7M" @default.
- NCIT_C103193 NCIT_P322 "CTRP" @default.
- NCIT_C103193 NCIT_P322 "FDA" @default.
- NCIT_C103193 NCIT_P329 "740779" @default.
- NCIT_C103193 NCIT_P330 "740779" @default.
- NCIT_C103193 NCIT_P399 "740779" @default.
- NCIT_C103193 normalizedInformationContent "100" @default.
- NCIT_C103193 referenceCount "1" @default.
- NCIT_C103193 hasExactSynonym "NEROFE" @default.
- NCIT_C103193 hasExactSynonym "Nerofe" @default.
- NCIT_C103193 hasExactSynonym "Tumor-Cells Apoptosis Factor Hormone-Peptide" @default.
- NCIT_C103193 inSubset NCIT_C116977 @default.
- NCIT_C103193 inSubset NCIT_C116978 @default.
- NCIT_C103193 inSubset NCIT_C128784 @default.
- NCIT_C103193 inSubset NCIT_C176424 @default.
- NCIT_C103193 inSubset NCIT_C63923 @default.
- NCIT_C103193 type Class @default.
- NCIT_C103193 isDefinedBy ncit.owl @default.
- NCIT_C103193 label "Tumor-Cells Apoptosis Factor Hormone-Peptide" @default.
- NCIT_C103193 subClassOf NCIT_C103193 @default.
- NCIT_C103193 subClassOf NCIT_C129821 @default.
- NCIT_C103193 subClassOf NCIT_C1742 @default.
- NCIT_C103193 subClassOf NCIT_C1908 @default.
- NCIT_C103193 subClassOf NCIT_C1909 @default.
- NCIT_C103193 subClassOf NCIT_C274 @default.
- NCIT_C103193 subClassOf NCIT_C307 @default.