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- NCIT_C103230 IAO_0000115 "A proprietary formulation consisting of a Phellodendron amurense (Amur cork tree) bark extract, often used in traditional Chinese medicine, with anti-inflammatory, anti-oxidant and potential chemopreventive and antineoplastic activities. Phellodendron amurense bark extract contains certain isoquinoline alkaloids, flavone glycosides and phenolic compounds. Upon administration of Phellodendron amurense bark extract, the various phytochemicals in this formulation modulate multiple signal transduction pathways. This agent appears to block the activation of the transcription factor cAMP response binding protein (CREB) and inhibits Akt signaling, thereby inhibiting tumor cell growth and inducing apoptosis in Akt- and CREB-overexpressing cancer cells. In addition, this agent inhibits cyclooxygenase type 2 (COX-2), nuclear factor kappa b (NF-kB) and tumor necrosis factor alpha (TNF-a)-mediated signaling; COX-2, NF-kB and TNF-a are upregulated in certain types of cancer and during inflammation." @default.
- NCIT_C103230 NCIT_A32 NCIT_C1909 @default.
- NCIT_C103230 NCIT_NHC0 "C103230" @default.
- NCIT_C103230 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C103230 NCIT_P107 "Phellodendron amurense Bark Extract" @default.
- NCIT_C103230 NCIT_P108 "Phellodendron amurense Bark Extract" @default.
- NCIT_C103230 NCIT_P207 "C3256251" @default.
- NCIT_C103230 NCIT_P319 "PBG27B754G" @default.
- NCIT_C103230 NCIT_P322 "CTRP" @default.
- NCIT_C103230 NCIT_P322 "FDA" @default.
- NCIT_C103230 NCIT_P322 "GDC" @default.
- NCIT_C103230 NCIT_P329 "741824" @default.
- NCIT_C103230 NCIT_P330 "741824" @default.
- NCIT_C103230 NCIT_P375 "Phellodendron amurense Bark Extract" @default.
- NCIT_C103230 NCIT_P399 "741824" @default.
- NCIT_C103230 normalizedInformationContent "100" @default.
- NCIT_C103230 referenceCount "1" @default.
- NCIT_C103230 hasExactSynonym "Nexrutine" @default.
- NCIT_C103230 hasExactSynonym "PHELLODENDRON AMURENSE BARK" @default.
- NCIT_C103230 hasExactSynonym "Phellodendron amurense Bark Extract" @default.
- NCIT_C103230 inSubset NCIT_C116977 @default.
- NCIT_C103230 inSubset NCIT_C116978 @default.
- NCIT_C103230 inSubset NCIT_C128784 @default.
- NCIT_C103230 inSubset NCIT_C157711 @default.
- NCIT_C103230 inSubset NCIT_C157712 @default.
- NCIT_C103230 inSubset NCIT_C176424 @default.
- NCIT_C103230 inSubset NCIT_C177537 @default.
- NCIT_C103230 inSubset NCIT_C63923 @default.
- NCIT_C103230 type Class @default.
- NCIT_C103230 isDefinedBy ncit.owl @default.
- NCIT_C103230 label "Phellodendron amurense Bark Extract" @default.
- NCIT_C103230 subClassOf NCIT_C103230 @default.
- NCIT_C103230 subClassOf NCIT_C1907 @default.
- NCIT_C103230 subClassOf NCIT_C1908 @default.
- NCIT_C103230 subClassOf NCIT_C1909 @default.
- NCIT_C103230 subClassOf NCIT_C1931 @default.
- NCIT_C103230 subClassOf NCIT_C274 @default.