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- NCIT_C103276 IAO_0000115 "A pegylated liposomal formulation comprised of a lipophilic prodrug of the antineoplastic antibiotic mitomycin C containing a cleavable disulfide bond (PL-MLP), with potential antineoplastic activity. Upon administration of the pegylated liposomal mitomycin C lipid-based prodrug, the MLP moiety becomes activated upon thiolysis at the tumor site, thereby releasing mitomycin C. Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. The thiolytic environment and upregulated expression of thioredoxins at the tumor site allow for the activation and release of mitomycin C. This prodrug formulation allows for greater circulation time, less systemic toxicity and increased accumulation of mitomycin C at the tumor site." @default.
- NCIT_C103276 NCIT_A32 NCIT_C1909 @default.
- NCIT_C103276 NCIT_NHC0 "C103276" @default.
- NCIT_C103276 NCIT_P106 "Antibiotic" @default.
- NCIT_C103276 NCIT_P106 "Organic Chemical" @default.
- NCIT_C103276 NCIT_P108 "Pegylated Liposomal Mitomycin C Lipid-based Prodrug" @default.
- NCIT_C103276 NCIT_P208 "CL438127" @default.
- NCIT_C103276 NCIT_P210 "303983-00-8" @default.
- NCIT_C103276 NCIT_P319 "3I8JKL1CHB" @default.
- NCIT_C103276 NCIT_P322 "FDA" @default.
- NCIT_C103276 NCIT_P322 "GDC" @default.
- NCIT_C103276 NCIT_P329 "741900" @default.
- NCIT_C103276 NCIT_P330 "741900" @default.
- NCIT_C103276 NCIT_P375 "Pegylated Liposomal Mitomycin C Lipid-based Prodrug" @default.
- NCIT_C103276 NCIT_P399 "741900" @default.
- NCIT_C103276 normalizedInformationContent "100" @default.
- NCIT_C103276 referenceCount "1" @default.
- NCIT_C103276 hasExactSynonym "JNJ-27548547" @default.
- NCIT_C103276 hasExactSynonym "PL-MLP" @default.
- NCIT_C103276 hasExactSynonym "Pegylated Liposomal Mitomycin C Lipid-based Prodrug" @default.
- NCIT_C103276 hasExactSynonym "Promitil" @default.
- NCIT_C103276 inSubset NCIT_C128784 @default.
- NCIT_C103276 inSubset NCIT_C157711 @default.
- NCIT_C103276 inSubset NCIT_C157712 @default.
- NCIT_C103276 inSubset NCIT_C176424 @default.
- NCIT_C103276 inSubset NCIT_C177537 @default.
- NCIT_C103276 inSubset NCIT_C63923 @default.
- NCIT_C103276 type Class @default.
- NCIT_C103276 isDefinedBy ncit.owl @default.
- NCIT_C103276 label "Pegylated Liposomal Mitomycin C Lipid-based Prodrug" @default.
- NCIT_C103276 subClassOf NCIT_C103276 @default.
- NCIT_C103276 subClassOf NCIT_C1590 @default.
- NCIT_C103276 subClassOf NCIT_C186664 @default.
- NCIT_C103276 subClassOf NCIT_C1908 @default.
- NCIT_C103276 subClassOf NCIT_C1909 @default.
- NCIT_C103276 subClassOf NCIT_C259 @default.
- NCIT_C103276 subClassOf NCIT_C274 @default.
- NCIT_C103276 subClassOf NCIT_C2842 @default.
- NCIT_C103276 subClassOf NCIT_C292 @default.
- NCIT_C103276 subClassOf NCIT_C663 @default.