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- NCIT_C103819 IAO_0000115 "The hydrochloride salt form of the quinazoline derivative erlotinib labeled with the positron-emitting isotope carbon C 11, with potential use in imaging. Competing with adenosine triphosphate, erlotinib reversibly binds to the intracellular catalytic tyrosine kinase domain of the epidermal growth factor receptor (EGFR). Following exposure to this agent, EGFR expression status can be determined and EGFR overexpressing tumor cells can be visualized using positron emission tomography (PET) imaging. This may be useful in determining the tumor cell response to a particular EGFR kinase inhibitor in individual patients. EGFR, a receptor tyrosine kinase, is overexpressed in numerous cancer cell types, and plays a significant role in tumor cell progression." @default.
- NCIT_C103819 NCIT_A7 NCIT_C17068 @default.
- NCIT_C103819 NCIT_NHC0 "C103819" @default.
- NCIT_C103819 NCIT_P106 "Indicator, Reagent, or Diagnostic Aid" @default.
- NCIT_C103819 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C103819 NCIT_P107 "Carbon C 11 Erlotinib Hydrochloride" @default.
- NCIT_C103819 NCIT_P108 "Carbon C 11 Erlotinib Hydrochloride" @default.
- NCIT_C103819 NCIT_P208 "CL438302" @default.
- NCIT_C103819 NCIT_P322 "CTRP" @default.
- NCIT_C103819 NCIT_P329 "742529" @default.
- NCIT_C103819 NCIT_P330 "742529" @default.
- NCIT_C103819 NCIT_P399 "742529" @default.
- NCIT_C103819 normalizedInformationContent "100" @default.
- NCIT_C103819 referenceCount "1" @default.
- NCIT_C103819 hasExactSynonym "C11-Erlotinib Hydrochloride" @default.
- NCIT_C103819 hasExactSynonym "Carbon C 11 Erlotinib Hydrochloride" @default.
- NCIT_C103819 inSubset NCIT_C116977 @default.
- NCIT_C103819 inSubset NCIT_C116978 @default.
- NCIT_C103819 inSubset NCIT_C176424 @default.
- NCIT_C103819 type Class @default.
- NCIT_C103819 isDefinedBy ncit.owl @default.
- NCIT_C103819 label "Carbon C 11 Erlotinib Hydrochloride" @default.
- NCIT_C103819 subClassOf NCIT_C103819 @default.
- NCIT_C103819 subClassOf NCIT_C1446 @default.
- NCIT_C103819 subClassOf NCIT_C1908 @default.
- NCIT_C103819 subClassOf NCIT_C1909 @default.
- NCIT_C103819 subClassOf NCIT_C2124 @default.