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- NCIT_C103824 IAO_0000115 "A prolonged-release tablet formulation composed of the hydrochloride salt form of the opioid receptor agonist oxycodone and the hydrochloride salt form of the opioid receptor antagonist naloxone which may produce analgesia while relieving opioid-mediated gastrointestinal (GI) side effects. Upon oral administration, oxycodone binds to opioid receptors, thereby mimicking the effects of endogenous opiates to provide analgesia. As naloxone is very poorly absorbed, this agent binds locally to opiate receptors in the GI tract, thereby preventing oxycodone from binding to these receptors. This relieves the opioid-related side effects on the GI tract, including opioid-induced constipation." @default.
- NCIT_C103824 NCIT_NHC0 "C103824" @default.
- NCIT_C103824 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C103824 NCIT_P108 "Oxycodone Hydrochloride/Naloxone Hydrochloride Prolonged-release Tablet" @default.
- NCIT_C103824 NCIT_P207 "C3180499" @default.
- NCIT_C103824 NCIT_P329 "742626" @default.
- NCIT_C103824 NCIT_P330 "742626" @default.
- NCIT_C103824 NCIT_P399 "742626" @default.
- NCIT_C103824 normalizedInformationContent "100" @default.
- NCIT_C103824 referenceCount "1" @default.
- NCIT_C103824 hasExactSynonym "Oxycodone Hydrochloride/Naloxone Hydrochloride Prolonged-release Tablet" @default.
- NCIT_C103824 hasExactSynonym "Targin" @default.
- NCIT_C103824 hasExactSynonym "Targinact" @default.
- NCIT_C103824 inSubset NCIT_C176424 @default.
- NCIT_C103824 type Class @default.
- NCIT_C103824 isDefinedBy ncit.owl @default.
- NCIT_C103824 label "Oxycodone Hydrochloride/Naloxone Hydrochloride Prolonged-release Tablet" @default.
- NCIT_C103824 subClassOf NCIT_C103824 @default.
- NCIT_C103824 subClassOf NCIT_C1908 @default.
- NCIT_C103824 subClassOf NCIT_C1909 @default.
- NCIT_C103824 subClassOf NCIT_C67413 @default.
- NCIT_C103824 subClassOf NCIT_C681 @default.
- NCIT_C103824 subClassOf NCIT_C78272 @default.