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- NCIT_C103827 IAO_0000115 "A recombinant T-cell engaging bispecific monoclonal antibody (BiTE) directed against human prostate specific membrane antigen (PSMA) and the CD3 epsilon subunit of the T cell receptor complex, with potential immunostimulating and antineoplastic activities. Pasotuxizumab possesses two antigen-recognition sites, one for PSMA, and one for the CD3 complex, a group of T cell surface glycoproteins that complex with the T cell receptor (TCR). This bispecific monoclonal antibody brings PSMA-expressing tumor cells and cytotoxic T lymphocytes (CTLs) together, which may result in the CTL-mediated cell death of PSMA-expressing cells. PSMA, a tumor associated antigen, is overexpressed on the surface of metastatic and hormone-refractory prostate cancer cells." @default.
- NCIT_C103827 NCIT_A32 NCIT_C1909 @default.
- NCIT_C103827 NCIT_NHC0 "C103827" @default.
- NCIT_C103827 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C103827 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C103827 NCIT_P108 "Pasotuxizumab" @default.
- NCIT_C103827 NCIT_P208 "CL438307" @default.
- NCIT_C103827 NCIT_P210 "1442657-12-6" @default.
- NCIT_C103827 NCIT_P319 "9J6SW7G28J" @default.
- NCIT_C103827 NCIT_P322 "FDA" @default.
- NCIT_C103827 NCIT_P322 "GDC" @default.
- NCIT_C103827 NCIT_P329 "742717" @default.
- NCIT_C103827 NCIT_P330 "742717" @default.
- NCIT_C103827 NCIT_P375 "Pasotuxizumab" @default.
- NCIT_C103827 NCIT_P399 "742717" @default.
- NCIT_C103827 NCIT_R124 NCIT_C17710 @default.
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- NCIT_C103827 NCIT_R124 NCIT_C18219 @default.
- NCIT_C103827 NCIT_R124 NCIT_C19986 @default.
- NCIT_C103827 NCIT_R124 NCIT_C40474 @default.
- NCIT_C103827 normalizedInformationContent "100" @default.
- NCIT_C103827 referenceCount "1" @default.
- NCIT_C103827 hasExactSynonym "AMG-212" @default.
- NCIT_C103827 hasExactSynonym "BAY2010112" @default.
- NCIT_C103827 hasExactSynonym "MT112" @default.
- NCIT_C103827 hasExactSynonym "PASOTUXIZUMAB" @default.
- NCIT_C103827 hasExactSynonym "Pasotuxizumab" @default.
- NCIT_C103827 inSubset NCIT_C128784 @default.
- NCIT_C103827 inSubset NCIT_C157711 @default.
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- NCIT_C103827 inSubset NCIT_C63923 @default.
- NCIT_C103827 type Class @default.
- NCIT_C103827 isDefinedBy ncit.owl @default.
- NCIT_C103827 label "Pasotuxizumab" @default.
- NCIT_C103827 subClassOf NCIT_C103827 @default.
- NCIT_C103827 subClassOf NCIT_C112883 @default.
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- NCIT_C103827 subClassOf NCIT_C201282 @default.
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- NCIT_C103827 subClassOf NCIT_C274 @default.
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- NCIT_C103827 subClassOf NCIT_C307 @default.
- NCIT_C103827 subClassOf NCIT_C308 @default.