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- NCIT_C103828 IAO_0000115 "A calixarene-based compound and galectin-1 (Gal-1) inhibitor with potential anti-angiogenic and antineoplastic activities. Upon subcutaneous administration, galectin-1 inhibitor OTX008 binds Gal-1 which leads to Gal-1 oxidation and proteasomal degradation, through an as of yet not fully elucidated mechanism, and eventually downregulation of Gal-1. This decreases tumor cell growth and inhibits angiogenesis. Gal-1, a multifunctional carbohydrate-binding protein, is often overexpressed on tumor cells and plays a key role in cancer cell proliferation, apoptosis, tumor angiogenesis and evasion of immune responses." @default.
- NCIT_C103828 NCIT_A32 NCIT_C1909 @default.
- NCIT_C103828 NCIT_NHC0 "C103828" @default.
- NCIT_C103828 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C103828 NCIT_P108 "Galectin-1 Inhibitor OTX008" @default.
- NCIT_C103828 NCIT_P207 "C3641630" @default.
- NCIT_C103828 NCIT_P210 "286936-40-1" @default.
- NCIT_C103828 NCIT_P319 "8JI63CFH5V" @default.
- NCIT_C103828 NCIT_P322 "FDA" @default.
- NCIT_C103828 NCIT_P322 "GDC" @default.
- NCIT_C103828 NCIT_P329 "742751" @default.
- NCIT_C103828 NCIT_P330 "742751" @default.
- NCIT_C103828 NCIT_P375 "Galectin-1 Inhibitor OTX008" @default.
- NCIT_C103828 NCIT_P399 "742751" @default.
- NCIT_C103828 normalizedInformationContent "100" @default.
- NCIT_C103828 referenceCount "1" @default.
- NCIT_C103828 hasExactSynonym "Gal-1 Inhibitor OTX008" @default.
- NCIT_C103828 hasExactSynonym "Galectin-1 Inhibitor OTX008" @default.
- NCIT_C103828 hasExactSynonym "KM-0118" @default.
- NCIT_C103828 hasExactSynonym "OTX-008" @default.
- NCIT_C103828 hasExactSynonym "OTX008" @default.
- NCIT_C103828 inSubset NCIT_C128784 @default.
- NCIT_C103828 inSubset NCIT_C157711 @default.
- NCIT_C103828 inSubset NCIT_C157712 @default.
- NCIT_C103828 inSubset NCIT_C176424 @default.
- NCIT_C103828 inSubset NCIT_C177537 @default.
- NCIT_C103828 inSubset NCIT_C63923 @default.
- NCIT_C103828 type Class @default.
- NCIT_C103828 isDefinedBy ncit.owl @default.
- NCIT_C103828 label "Galectin-1 Inhibitor OTX008" @default.
- NCIT_C103828 subClassOf NCIT_C103828 @default.
- NCIT_C103828 subClassOf NCIT_C129824 @default.
- NCIT_C103828 subClassOf NCIT_C1742 @default.
- NCIT_C103828 subClassOf NCIT_C1908 @default.
- NCIT_C103828 subClassOf NCIT_C1909 @default.
- NCIT_C103828 subClassOf NCIT_C2189 @default.
- NCIT_C103828 subClassOf NCIT_C274 @default.