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- NCIT_C103858 IAO_0000115 "A 9 amino acid-based cyclic, tumor specific homing, arginine-glycine-aspartic acid (RGD)-based peptide (CRGDKRGPDC), with tumor penetrating activity. The iRGD contains the RGD motif as well as the C-terminal end binding (CendR) motif that increases internalization. Upon administration, the RGD motif of the iRGD peptide is able to specifically target tumors by binding to alphavbeta3/alphavbeta5 integrins on tumor endothelium. In turn, iRGD is cleaved by specific tumor proteases, which exposes the positively charged CendR motif. This motif binds to neuropilin-1 (NRP-1), a receptor overexpressed on certain tumor cells. This increases vascular permeability of tumor blood vessels and promotes tumor penetration. Compared to other RGD peptides, this agent is able to both improve delivery and increase the accumulation of co-administered or conjugated chemotherapeutic agents in the tumor." @default.
- NCIT_C103858 NCIT_A7 NCIT_C38953 @default.
- NCIT_C103858 NCIT_A7 NCIT_C53624 @default.
- NCIT_C103858 NCIT_NHC0 "C103858" @default.
- NCIT_C103858 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C103858 NCIT_P107 "Internalized-arginylglycylaspartic Acid Cyclic Peptide" @default.
- NCIT_C103858 NCIT_P108 "Internalized-arginylglycylaspartic Acid Cyclic Peptide" @default.
- NCIT_C103858 NCIT_P208 "CL438336" @default.
- NCIT_C103858 NCIT_P210 "1392278-76-0" @default.
- NCIT_C103858 NCIT_P319 "Z8MXU5GH4Q" @default.
- NCIT_C103858 NCIT_P322 "CTRP" @default.
- NCIT_C103858 NCIT_P322 "FDA" @default.
- NCIT_C103858 NCIT_P329 "743105" @default.
- NCIT_C103858 NCIT_P330 "743105" @default.
- NCIT_C103858 NCIT_P399 "743105" @default.
- NCIT_C103858 normalizedInformationContent "100" @default.
- NCIT_C103858 referenceCount "1" @default.
- NCIT_C103858 hasExactSynonym "CEND 1" @default.
- NCIT_C103858 hasExactSynonym "CEND-1" @default.
- NCIT_C103858 hasExactSynonym "IRGD" @default.
- NCIT_C103858 hasExactSynonym "Internalized-arginylglycylaspartic Acid Cyclic Peptide" @default.
- NCIT_C103858 hasExactSynonym "L-Cysteine, L-Cysteinyl-L-Arginylglycyl-L-.Alpha.-Aspartyl-L-Lysylglycyl-L-Prolyl-L-.Alpha.-Aspartyl-, Cyclic (1->9)-Disulfide" @default.
- NCIT_C103858 hasExactSynonym "LSTA 1" @default.
- NCIT_C103858 hasExactSynonym "LSTA-1" @default.
- NCIT_C103858 hasExactSynonym "LSTA1" @default.
- NCIT_C103858 hasExactSynonym "iRGD" @default.
- NCIT_C103858 inSubset NCIT_C116977 @default.
- NCIT_C103858 inSubset NCIT_C116978 @default.
- NCIT_C103858 inSubset NCIT_C176424 @default.
- NCIT_C103858 inSubset NCIT_C63923 @default.
- NCIT_C103858 type Class @default.
- NCIT_C103858 isDefinedBy ncit.owl @default.
- NCIT_C103858 label "Internalized-arginylglycylaspartic Acid Cyclic Peptide" @default.
- NCIT_C103858 subClassOf NCIT_C103858 @default.
- NCIT_C103858 subClassOf NCIT_C1908 @default.
- NCIT_C103858 subClassOf NCIT_C1909 @default.
- NCIT_C103858 subClassOf NCIT_C2140 @default.