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- NCIT_C103859 IAO_0000115 "A human monoclonal antibody directed against the human epidermal growth factor receptor ErbB3 (Her3) with potential antineoplastic activity. Upon administration, anti-ErbB3 monoclonal antibody REGN1400 binds to ErbB3 and prevents neuregulin 1 ligand binding to ErbB3, which may result in an inhibition of ErbB3-dependent phosphatidylinositol-3 kinase (PI3K)/Akt signaling. This eventually leads to the inhibition of cellular proliferation and differentiation. ErbB3, a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases, is frequently overexpressed in a variety of solid tumors and its overexpression generally correlates with poor prognosis and tumor resistance." @default.
- NCIT_C103859 NCIT_A32 NCIT_C1909 @default.
- NCIT_C103859 NCIT_NHC0 "C103859" @default.
- NCIT_C103859 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C103859 NCIT_P108 "Anti-ErbB3 Monoclonal Antibody REGN1400" @default.
- NCIT_C103859 NCIT_P208 "CL438337" @default.
- NCIT_C103859 NCIT_P210 "1443016-81-6" @default.
- NCIT_C103859 NCIT_P319 "93F274N35Z" @default.
- NCIT_C103859 NCIT_P322 "FDA" @default.
- NCIT_C103859 NCIT_P322 "GDC" @default.
- NCIT_C103859 NCIT_P329 "743118" @default.
- NCIT_C103859 NCIT_P330 "743118" @default.
- NCIT_C103859 NCIT_P375 "Anti-ErbB3 Monoclonal Antibody REGN1400" @default.
- NCIT_C103859 NCIT_P399 "743118" @default.
- NCIT_C103859 NCIT_R124 NCIT_C17710 @default.
- NCIT_C103859 NCIT_R124 NCIT_C17828 @default.
- NCIT_C103859 NCIT_R124 NCIT_C18219 @default.
- NCIT_C103859 NCIT_R124 NCIT_C19986 @default.
- NCIT_C103859 NCIT_R124 NCIT_C40474 @default.
- NCIT_C103859 normalizedInformationContent "100" @default.
- NCIT_C103859 referenceCount "1" @default.
- NCIT_C103859 hasExactSynonym "Anti-ErbB3 Monoclonal Antibody REGN1400" @default.
- NCIT_C103859 hasExactSynonym "REGN 1400" @default.
- NCIT_C103859 hasExactSynonym "REGN-1400" @default.
- NCIT_C103859 hasExactSynonym "REGN1400" @default.
- NCIT_C103859 inSubset NCIT_C128784 @default.
- NCIT_C103859 inSubset NCIT_C157711 @default.
- NCIT_C103859 inSubset NCIT_C157712 @default.
- NCIT_C103859 inSubset NCIT_C176424 @default.
- NCIT_C103859 inSubset NCIT_C177537 @default.
- NCIT_C103859 inSubset NCIT_C63923 @default.
- NCIT_C103859 type Class @default.
- NCIT_C103859 isDefinedBy ncit.owl @default.
- NCIT_C103859 label "Anti-ErbB3 Monoclonal Antibody REGN1400" @default.
- NCIT_C103859 subClassOf NCIT_C103859 @default.
- NCIT_C103859 subClassOf NCIT_C129821 @default.
- NCIT_C103859 subClassOf NCIT_C129822 @default.
- NCIT_C103859 subClassOf NCIT_C163758 @default.
- NCIT_C103859 subClassOf NCIT_C1908 @default.
- NCIT_C103859 subClassOf NCIT_C1909 @default.
- NCIT_C103859 subClassOf NCIT_C199383 @default.
- NCIT_C103859 subClassOf NCIT_C199386 @default.
- NCIT_C103859 subClassOf NCIT_C20401 @default.
- NCIT_C103859 subClassOf NCIT_C274 @default.
- NCIT_C103859 subClassOf NCIT_C307 @default.
- NCIT_C103859 subClassOf NCIT_C308 @default.