Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C103860> ?p ?o ?g. }
Showing items 1 to 44 of
44
with 100 items per page.
- NCIT_C103860 IAO_0000115 "A humanized IgG4 monoclonal antibody that targets the human leukocyte antigen HLA-DR, with potential antineoplastic activity. Upon administration, anti-HLA-DR monoclonal antibody IMMU-114 binds to HLA-DR on HLA-DR-expressing tumor cells and, although the exact mechanism has yet to be fully elucidated, appears to induce hyperactivation of ERK- and JNK-dependent mitogen activated protein kinase signaling pathways. This may lead to mitochondrial membrane depolarization and reactive oxygen species (ROS) generation. This eventually leads to an induction of tumor cell apoptosis and a reduction in tumor cell proliferation. IMMU-14 may be beneficial in the treatment of graft versus host disease (GVHD) as it appears to suppress T-lymphocyte proliferation and natural killer (NK) cell activation. As the Fc region of the orgnial IgG1 MoAb was replaced with the IgG4 isotype, IMMU-114 does not induce a complement cytotoxicity (CDC) or an antibody-dependent cell-mediated cytotoxicity (ADCC). HLA-DR, a MHC class II molecule, is found on various b-cell hematologic malignancies and in autoimmune diseases as well as on normal cells." @default.
- NCIT_C103860 NCIT_A32 NCIT_C1909 @default.
- NCIT_C103860 NCIT_A7 NCIT_C16692 @default.
- NCIT_C103860 NCIT_NHC0 "C103860" @default.
- NCIT_C103860 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C103860 NCIT_P107 "Anti-HLA-DR Monoclonal Antibody IMMU-114" @default.
- NCIT_C103860 NCIT_P108 "Anti-HLA-DR Monoclonal Antibody IMMU-114" @default.
- NCIT_C103860 NCIT_P207 "C3530137" @default.
- NCIT_C103860 NCIT_P322 "CTRP" @default.
- NCIT_C103860 NCIT_P322 "GDC" @default.
- NCIT_C103860 NCIT_P329 "743255" @default.
- NCIT_C103860 NCIT_P330 "743255" @default.
- NCIT_C103860 NCIT_P375 "Anti-HLA-DR Monoclonal Antibody IMMU-114" @default.
- NCIT_C103860 NCIT_P399 "743255" @default.
- NCIT_C103860 NCIT_R124 NCIT_C17710 @default.
- NCIT_C103860 NCIT_R124 NCIT_C17828 @default.
- NCIT_C103860 NCIT_R124 NCIT_C18219 @default.
- NCIT_C103860 NCIT_R124 NCIT_C19986 @default.
- NCIT_C103860 NCIT_R124 NCIT_C40474 @default.
- NCIT_C103860 normalizedInformationContent "100" @default.
- NCIT_C103860 referenceCount "1" @default.
- NCIT_C103860 hasExactSynonym "Anti-HLA-DR MoAb L243" @default.
- NCIT_C103860 hasExactSynonym "Anti-HLA-DR Monoclonal Antibody IMMU-114" @default.
- NCIT_C103860 hasExactSynonym "IMMU-114" @default.
- NCIT_C103860 hasExactSynonym "hL243gamma4P" @default.
- NCIT_C103860 inSubset NCIT_C116977 @default.
- NCIT_C103860 inSubset NCIT_C116978 @default.
- NCIT_C103860 inSubset NCIT_C128784 @default.
- NCIT_C103860 inSubset NCIT_C157711 @default.
- NCIT_C103860 inSubset NCIT_C157712 @default.
- NCIT_C103860 inSubset NCIT_C176424 @default.
- NCIT_C103860 inSubset NCIT_C177537 @default.
- NCIT_C103860 type Class @default.
- NCIT_C103860 isDefinedBy ncit.owl @default.
- NCIT_C103860 label "Anti-HLA-DR Monoclonal Antibody IMMU-114" @default.
- NCIT_C103860 subClassOf NCIT_C103860 @default.
- NCIT_C103860 subClassOf NCIT_C129821 @default.
- NCIT_C103860 subClassOf NCIT_C129822 @default.
- NCIT_C103860 subClassOf NCIT_C1908 @default.
- NCIT_C103860 subClassOf NCIT_C1909 @default.
- NCIT_C103860 subClassOf NCIT_C20401 @default.
- NCIT_C103860 subClassOf NCIT_C274 @default.
- NCIT_C103860 subClassOf NCIT_C307 @default.
- NCIT_C103860 subClassOf NCIT_C308 @default.