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- NCIT_C103861 IAO_0000115 "An orally bioavailable inhibitor of the class I phosphoinositide 3-kinase (PI3K) alpha and beta isoforms with potential antineoplastic activity. PI3K alpha/beta inhibitor BAY1082439 selectively inhibits both PI3K alpha, including mutated forms of PIK3CA, and PI3K beta in the PI3K/Akt/mTOR pathway, which may result in tumor cell apoptosis and growth inhibition in PI3K-expressing and/or PTEN-driven tumor cells. By specifically targeting class I PI3K alpha and beta, this agent may be more efficacious and less toxic than pan PI3K inhibitors. Dysregulation of the PI3K/Akt/mTOR pathway is frequently found in solid tumors and results in increased tumor cell growth, survival, and resistance to chemotherapy and radiotherapy. PIK3CA, one of the most highly mutated oncogenes, encodes the p110-alpha catalytic subunit of the class I PI3K. PTEN, a tumor suppressor protein and negative regulator of PI3K activity, is often mutated in a variety of cancer cells." @default.
- NCIT_C103861 NCIT_A32 NCIT_C1909 @default.
- NCIT_C103861 NCIT_NHC0 "C103861" @default.
- NCIT_C103861 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C103861 NCIT_P108 "PI3K Alpha/Beta Inhibitor BAY1082439" @default.
- NCIT_C103861 NCIT_P208 "CL438339" @default.
- NCIT_C103861 NCIT_P210 "1375469-38-7" @default.
- NCIT_C103861 NCIT_P319 "59784ZX4GD" @default.
- NCIT_C103861 NCIT_P322 "FDA" @default.
- NCIT_C103861 NCIT_P322 "GDC" @default.
- NCIT_C103861 NCIT_P329 "743262" @default.
- NCIT_C103861 NCIT_P330 "743262" @default.
- NCIT_C103861 NCIT_P375 "PI3K Alpha/Beta Inhibitor BAY1082439" @default.
- NCIT_C103861 NCIT_P399 "743262" @default.
- NCIT_C103861 normalizedInformationContent "100" @default.
- NCIT_C103861 referenceCount "1" @default.
- NCIT_C103861 hasExactSynonym "BAY-1082439" @default.
- NCIT_C103861 hasExactSynonym "BAY1082439" @default.
- NCIT_C103861 hasExactSynonym "PI3K Alpha/Beta Inhibitor BAY1082439" @default.
- NCIT_C103861 inSubset NCIT_C128784 @default.
- NCIT_C103861 inSubset NCIT_C157711 @default.
- NCIT_C103861 inSubset NCIT_C157712 @default.
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- NCIT_C103861 inSubset NCIT_C63923 @default.
- NCIT_C103861 type Class @default.
- NCIT_C103861 isDefinedBy ncit.owl @default.
- NCIT_C103861 label "PI3K Alpha/Beta Inhibitor BAY1082439" @default.
- NCIT_C103861 subClassOf NCIT_C103861 @default.
- NCIT_C103861 subClassOf NCIT_C129824 @default.
- NCIT_C103861 subClassOf NCIT_C129825 @default.
- NCIT_C103861 subClassOf NCIT_C1404 @default.
- NCIT_C103861 subClassOf NCIT_C163758 @default.
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- NCIT_C103861 subClassOf NCIT_C1908 @default.
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- NCIT_C103861 subClassOf NCIT_C471 @default.