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- NCIT_C103863 IAO_0000115 "A bispecific monoclonal antibody directed against the human epidermal growth factor receptor ErbB3 (Her3) and the human insulin-like growth factor-1 receptor (IGF-1R), with potential antineoplastic activity. The anti-IGF-1R targeting arm of Istiratumab binds to IGF-1R on tumor cells thereby preventing the binding of the natural ligands IGF-1, 2 and heregulin (HRG) to IGF-1R; the anti-ErbB3 therapeutic arm prevents the binding of neuregulin (NRG) to ErbB3. This prevents the activation of the PI3K/AKT signal transduction pathway and may result in both the induction of apoptosis and a decrease in cellular proliferation in IGF-1R and ErbB3-overexpressing tumor cells. IGF-1R, a receptor tyrosine kinase of the insulin receptor superfamily, and ErB3, a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases, are frequently overexpressed in solid tumors." @default.
- NCIT_C103863 NCIT_A32 NCIT_C1909 @default.
- NCIT_C103863 NCIT_A7 NCIT_C17531 @default.
- NCIT_C103863 NCIT_A7 NCIT_C18490 @default.
- NCIT_C103863 NCIT_NHC0 "C103863" @default.
- NCIT_C103863 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C103863 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C103863 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C103863 NCIT_P107 "Istiratumab" @default.
- NCIT_C103863 NCIT_P108 "Istiratumab" @default.
- NCIT_C103863 NCIT_P207 "C3641662" @default.
- NCIT_C103863 NCIT_P210 "1509928-04-4" @default.
- NCIT_C103863 NCIT_P319 "XLR461MD3M" @default.
- NCIT_C103863 NCIT_P322 "CTRP" @default.
- NCIT_C103863 NCIT_P322 "FDA" @default.
- NCIT_C103863 NCIT_P322 "GDC" @default.
- NCIT_C103863 NCIT_P329 "743370" @default.
- NCIT_C103863 NCIT_P330 "743370" @default.
- NCIT_C103863 NCIT_P375 "Anti-ErbB3/Anti-IGF-1R Bispecific Monoclonal Antibody MM-141" @default.
- NCIT_C103863 NCIT_P375 "Istiratumab" @default.
- NCIT_C103863 NCIT_P399 "743370" @default.
- NCIT_C103863 NCIT_R124 NCIT_C17710 @default.
- NCIT_C103863 NCIT_R124 NCIT_C17828 @default.
- NCIT_C103863 NCIT_R124 NCIT_C18219 @default.
- NCIT_C103863 NCIT_R124 NCIT_C19986 @default.
- NCIT_C103863 NCIT_R124 NCIT_C40474 @default.
- NCIT_C103863 normalizedInformationContent "100" @default.
- NCIT_C103863 referenceCount "1" @default.
- NCIT_C103863 hasExactSynonym "ISTIRATUMAB" @default.
- NCIT_C103863 hasExactSynonym "Istiratumab" @default.
- NCIT_C103863 hasExactSynonym "MM-005" @default.
- NCIT_C103863 hasExactSynonym "MM-141" @default.
- NCIT_C103863 inSubset NCIT_C116977 @default.
- NCIT_C103863 inSubset NCIT_C116978 @default.
- NCIT_C103863 inSubset NCIT_C128784 @default.
- NCIT_C103863 inSubset NCIT_C157711 @default.
- NCIT_C103863 inSubset NCIT_C157712 @default.
- NCIT_C103863 inSubset NCIT_C176424 @default.
- NCIT_C103863 inSubset NCIT_C177537 @default.
- NCIT_C103863 inSubset NCIT_C63923 @default.
- NCIT_C103863 type Class @default.
- NCIT_C103863 isDefinedBy ncit.owl @default.
- NCIT_C103863 label "Istiratumab" @default.
- NCIT_C103863 subClassOf NCIT_C103863 @default.
- NCIT_C103863 subClassOf NCIT_C129821 @default.
- NCIT_C103863 subClassOf NCIT_C129822 @default.
- NCIT_C103863 subClassOf NCIT_C1454 @default.
- NCIT_C103863 subClassOf NCIT_C1908 @default.
- NCIT_C103863 subClassOf NCIT_C1909 @default.
- NCIT_C103863 subClassOf NCIT_C20401 @default.
- NCIT_C103863 subClassOf NCIT_C274 @default.
- NCIT_C103863 subClassOf NCIT_C28227 @default.
- NCIT_C103863 subClassOf NCIT_C307 @default.
- NCIT_C103863 subClassOf NCIT_C308 @default.