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- NCIT_C104007 IAO_0000115 "A radiopharmaceutical agent comprised of a pegylated arginine-glycine-aspartic acid (RGD) dimer (PRGD2) labeled with technetium Tc 99m, with potential alphaVbeta3 integrin imaging activity when used with single photon emission computed tomography (SPECT). After intravenous administration of technetium Tc 99m-3PRGD2, the RGD moiety binds to alphaVbeta3 integrin on the cell membrane via the cyclic RGD motif. Upon PET imaging, alphaVbeta3 integrin-expressing tumor cells can be visualized and expression levels can be quantified. Compared to other radiolabeled RGD-containing peptides, this agent shows an increased affinity for alphaVbeta3 integrin, enhanced tumor uptake as well as improved pharmacokinetics. AlphaVbeta3 integrin, a member of the integrin receptor family, is overexpressed on certain tumor cells and tumor endothelial cells while minimally or not expressed on healthy, normal cells; this receptor plays a key role in angiogenesis, tumor proliferation and survival." @default.
- NCIT_C104007 NCIT_NHC0 "C104007" @default.
- NCIT_C104007 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C104007 NCIT_P108 "Technetium Tc 99m-3PRGD2" @default.
- NCIT_C104007 NCIT_P208 "CL438389" @default.
- NCIT_C104007 NCIT_P329 "743647" @default.
- NCIT_C104007 NCIT_P330 "743647" @default.
- NCIT_C104007 NCIT_P399 "743647" @default.
- NCIT_C104007 normalizedInformationContent "100" @default.
- NCIT_C104007 referenceCount "1" @default.
- NCIT_C104007 hasExactSynonym "(99m)Tc-PEG(4)-E[PEG(4)-c(RGDfK)](2) ((99m)Tc-3PRGD2)" @default.
- NCIT_C104007 hasExactSynonym "99mTc-3PRGD2" @default.
- NCIT_C104007 hasExactSynonym "Technetium Tc 99m-3PRGD2" @default.
- NCIT_C104007 inSubset NCIT_C176424 @default.
- NCIT_C104007 type Class @default.
- NCIT_C104007 isDefinedBy ncit.owl @default.
- NCIT_C104007 label "Technetium Tc 99m-3PRGD2" @default.
- NCIT_C104007 subClassOf NCIT_C104007 @default.
- NCIT_C104007 subClassOf NCIT_C1446 @default.
- NCIT_C104007 subClassOf NCIT_C1908 @default.
- NCIT_C104007 subClassOf NCIT_C1909 @default.
- NCIT_C104007 subClassOf NCIT_C2124 @default.