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- NCIT_C104008 IAO_0000115 "An orally bioavailable inhibitor of both phosphoinositide 3-kinase (PI3K) class I and pan histone deacetylase (HDAC) enzymes, with potential antineoplastic activity. Upon oral administration, fimepinostat inhibits the activity of both PI3K class I isoforms and HDAC, thereby preventing the activation of the PI3K-AKT-mTOR signal transduction pathway that is often overactivated in many cancer cell types. This may prevent growth of PI3K and/or HDAC-expressing tumor cells. CUDC-907 shows an increased inhibition of tumor cell growth and induction of apoptosis when compared to inhibitors that target either PI3K or HDAC." @default.
- NCIT_C104008 NCIT_A32 NCIT_C1909 @default.
- NCIT_C104008 NCIT_NHC0 "C104008" @default.
- NCIT_C104008 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C104008 NCIT_P107 "Fimepinostat" @default.
- NCIT_C104008 NCIT_P108 "Fimepinostat" @default.
- NCIT_C104008 NCIT_P207 "C3530053" @default.
- NCIT_C104008 NCIT_P210 "1339928-25-4" @default.
- NCIT_C104008 NCIT_P319 "3S9RX35S5X" @default.
- NCIT_C104008 NCIT_P322 "CTRP" @default.
- NCIT_C104008 NCIT_P322 "FDA" @default.
- NCIT_C104008 NCIT_P322 "GDC" @default.
- NCIT_C104008 NCIT_P329 "743908" @default.
- NCIT_C104008 NCIT_P330 "743908" @default.
- NCIT_C104008 NCIT_P375 "Fimepinostat" @default.
- NCIT_C104008 NCIT_P399 "743908" @default.
- NCIT_C104008 normalizedInformationContent "100" @default.
- NCIT_C104008 referenceCount "1" @default.
- NCIT_C104008 hasExactSynonym "CUDC-907" @default.
- NCIT_C104008 hasExactSynonym "FIMEPINOSTAT" @default.
- NCIT_C104008 hasExactSynonym "Fimepinostat" @default.
- NCIT_C104008 inSubset NCIT_C116977 @default.
- NCIT_C104008 inSubset NCIT_C116978 @default.
- NCIT_C104008 inSubset NCIT_C128784 @default.
- NCIT_C104008 inSubset NCIT_C157711 @default.
- NCIT_C104008 inSubset NCIT_C157712 @default.
- NCIT_C104008 inSubset NCIT_C176424 @default.
- NCIT_C104008 inSubset NCIT_C177537 @default.
- NCIT_C104008 inSubset NCIT_C63923 @default.
- NCIT_C104008 type Class @default.
- NCIT_C104008 isDefinedBy ncit.owl @default.
- NCIT_C104008 label "Fimepinostat" @default.
- NCIT_C104008 subClassOf NCIT_C104008 @default.
- NCIT_C104008 subClassOf NCIT_C129824 @default.
- NCIT_C104008 subClassOf NCIT_C129825 @default.
- NCIT_C104008 subClassOf NCIT_C1404 @default.
- NCIT_C104008 subClassOf NCIT_C163758 @default.
- NCIT_C104008 subClassOf NCIT_C1742 @default.
- NCIT_C104008 subClassOf NCIT_C1908 @default.
- NCIT_C104008 subClassOf NCIT_C1909 @default.
- NCIT_C104008 subClassOf NCIT_C1946 @default.
- NCIT_C104008 subClassOf NCIT_C2152 @default.
- NCIT_C104008 subClassOf NCIT_C2189 @default.
- NCIT_C104008 subClassOf NCIT_C274 @default.
- NCIT_C104008 subClassOf NCIT_C471 @default.