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- NCIT_C104009 IAO_0000115 "A preparation of polyclonal autologous CD8 positive T-lymphocytes specific for the Merkel cell polyomavirus (MCPyV) T antigen (TAg) with potential antineoplastic activity. Peripheral blood lymphocytes from a Merkel cell carcinoma (MCC) patient were obtained and antigen-specific CD8+ T cells targeting a specific MCPyV TAg epitope were derived and expanded ex vivo. Upon infusion of the MCPyV TAg-specific polyclonal autologous CD8-positive T cell vaccine, the T cells recognize the MCPyV antigen and exert a cytotoxic T-lymphocyte response against the MCPyV TAg-expressing MCC cells. MCPyV is expressed in about 80% of MCC and is not expressed in normal, human tissue; the MCPyVTag oncoprotein plays a key role in MCC survival and tumor cell proliferation." @default.
- NCIT_C104009 NCIT_NHC0 "C104009" @default.
- NCIT_C104009 NCIT_P106 "Cell" @default.
- NCIT_C104009 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C104009 NCIT_P107 "MCPyV TAg-specific Polyclonal Autologous CD8-positive T Cells" @default.
- NCIT_C104009 NCIT_P108 "MCPyV TAg-specific Polyclonal Autologous CD8-positive T Cells" @default.
- NCIT_C104009 NCIT_P208 "CL438391" @default.
- NCIT_C104009 NCIT_P322 "CTRP" @default.
- NCIT_C104009 NCIT_P329 "743909" @default.
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- NCIT_C104009 hasExactSynonym "MCPyV TAg-specific Polyclonal Autologous CD8-positive T Cells" @default.
- NCIT_C104009 inSubset NCIT_C116977 @default.
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- NCIT_C104009 type Class @default.
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- NCIT_C104009 label "MCPyV TAg-specific Polyclonal Autologous CD8-positive T Cells" @default.
- NCIT_C104009 subClassOf NCIT_C104009 @default.
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