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- NCIT_C104010 IAO_0000115 "A radioimmunoconjugate containing a glycoengineered, humanized monoclonal antibody directed against the human epidermal growth factor receptor HER3 (ErbB3) and labeled with the radioisotope zirconium Zr 89, with radioisotopic activity and potential use as an imaging agent as well as potential antineoplastic activity. Upon administration, the RO5479599 moiety of zirconium Zn 89-labeled RO5479599 binds to the extracellular domain of HER3 and inhibits HER3 dimerization, thereby preventing EGFR-dependent signaling. In addition, RO5479599 elicits enhanced antibody-dependent cellular cytotoxicity (ADCC). Upon binding, the radioisotope moiety may be detected using positron emission tomography (PET), thereby allowing the imaging and quantification of HER3-expressing tumor cells. HER3, a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases, is frequently overexpressed in tumors; it has no active kinase domain but is activated through heterodimerization with other members of the EGFR receptor family, such as HER2." @default.
- NCIT_C104010 NCIT_NHC0 "C104010" @default.
- NCIT_C104010 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C104010 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C104010 NCIT_P108 "Zirconium Zr 89-labeled RO5479599" @default.
- NCIT_C104010 NCIT_P208 "CL438392" @default.
- NCIT_C104010 NCIT_P329 "744006" @default.
- NCIT_C104010 NCIT_P330 "744006" @default.
- NCIT_C104010 NCIT_P399 "744006" @default.
- NCIT_C104010 normalizedInformationContent "100" @default.
- NCIT_C104010 referenceCount "1" @default.
- NCIT_C104010 hasExactSynonym "89Zr-RO5479599" @default.
- NCIT_C104010 hasExactSynonym "89Zr-labeled RO5479599" @default.
- NCIT_C104010 hasExactSynonym "Zirconium Zr 89-labeled RO5479599" @default.
- NCIT_C104010 inSubset NCIT_C176424 @default.
- NCIT_C104010 type Class @default.
- NCIT_C104010 isDefinedBy ncit.owl @default.
- NCIT_C104010 label "Zirconium Zr 89-labeled RO5479599" @default.
- NCIT_C104010 subClassOf NCIT_C104010 @default.
- NCIT_C104010 subClassOf NCIT_C1446 @default.
- NCIT_C104010 subClassOf NCIT_C1511 @default.
- NCIT_C104010 subClassOf NCIT_C1512 @default.
- NCIT_C104010 subClassOf NCIT_C1908 @default.
- NCIT_C104010 subClassOf NCIT_C1909 @default.
- NCIT_C104010 subClassOf NCIT_C2124 @default.
- NCIT_C104010 subClassOf NCIT_C307 @default.
- NCIT_C104010 subClassOf NCIT_C308 @default.