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- NCIT_C104012 IAO_0000115 "A soluble, recombinant fusion protein composed of a modified form of the extracellular domain of human activin receptor type IIb (ActRIIb) and linked to the human IgG1 Fc domain, with red blood cell stimulating activity. Upon subcutaneous administration, luspatercept inhibits several ligands in the transforming growth factor (TGF)-beta superfamily. This prevents activation of a variety of TGF-beta superfamily members involved in late stage erythropoiesis and results in an increased differentiation and proliferation of erythroid progenitors. luspatercept acts at a different, later stage than erythropoietin. This agent ultimately enhances red blood cell production and prevents anemia." @default.
- NCIT_C104012 NCIT_NHC0 "C104012" @default.
- NCIT_C104012 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C104012 NCIT_P107 "Luspatercept" @default.
- NCIT_C104012 NCIT_P108 "Luspatercept" @default.
- NCIT_C104012 NCIT_P208 "CL438394" @default.
- NCIT_C104012 NCIT_P210 "1373715-00-4" @default.
- NCIT_C104012 NCIT_P302 "treatment of anemia failing an erythropoiesis stimulating agent and requiring 2 or more red blood cell (RBC) units over 8 weeks in adult patients with very low- to intermediate-risk myelodysplastic syndromes with ring sideroblasts (MDS-RS) or with myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T)." @default.
- NCIT_C104012 NCIT_P319 "AQK7UBA1LS" @default.
- NCIT_C104012 NCIT_P322 "CTRP" @default.
- NCIT_C104012 NCIT_P322 "FDA" @default.
- NCIT_C104012 NCIT_P329 "744051" @default.
- NCIT_C104012 NCIT_P330 "744051" @default.
- NCIT_C104012 NCIT_P399 "744051" @default.
- NCIT_C104012 normalizedInformationContent "100" @default.
- NCIT_C104012 referenceCount "1" @default.
- NCIT_C104012 hasExactSynonym "(79-L-aspartic Acid(L>D))Human Activin Receptor Type-2B (ACTR-IIB, EC=2.7.11.30) Precursor-(25-131)-peptide (Extracellular Domain Fragment) Fusion Protein with Triglycyl-human Immunoglobulin Heavy Constant Gamma 1 Fc Fragment-(8-232)-peptide Dimer (114-114':117-117')-bisdisulfide" @default.
- NCIT_C104012 hasExactSynonym "ACE-536" @default.
- NCIT_C104012 hasExactSynonym "LUSPATERCEPT" @default.
- NCIT_C104012 hasExactSynonym "Luspatercept" @default.
- NCIT_C104012 hasExactSynonym "Luspatercept-aamt" @default.
- NCIT_C104012 hasExactSynonym "Reblozyl" @default.
- NCIT_C104012 inSubset NCIT_C116977 @default.
- NCIT_C104012 inSubset NCIT_C116978 @default.
- NCIT_C104012 inSubset NCIT_C176424 @default.
- NCIT_C104012 inSubset NCIT_C63923 @default.
- NCIT_C104012 type Class @default.
- NCIT_C104012 isDefinedBy ncit.owl @default.
- NCIT_C104012 label "Luspatercept" @default.
- NCIT_C104012 subClassOf NCIT_C104012 @default.
- NCIT_C104012 subClassOf NCIT_C1908 @default.
- NCIT_C104012 subClassOf NCIT_C1909 @default.
- NCIT_C104012 subClassOf NCIT_C307 @default.