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- NCIT_C104045 IAO_0000115 "An orally available inhibitor of extracellular signal-regulated kinase (ERK), with potential antineoplastic activity. Upon oral administration, MK-8353 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways; thereby, preventing ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is often upregulated in a variety of tumor cell types and plays a role in tumor cell proliferation, differentiation and survival." @default.
- NCIT_C104045 NCIT_A32 NCIT_C1909 @default.
- NCIT_C104045 NCIT_A7 NCIT_C16376 @default.
- NCIT_C104045 NCIT_NHC0 "C104045" @default.
- NCIT_C104045 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C104045 NCIT_P107 "ERK Inhibitor MK-8353" @default.
- NCIT_C104045 NCIT_P108 "ERK Inhibitor MK-8353" @default.
- NCIT_C104045 NCIT_P208 "CL433840" @default.
- NCIT_C104045 NCIT_P322 "CTRP" @default.
- NCIT_C104045 NCIT_P322 "GDC" @default.
- NCIT_C104045 NCIT_P329 "701114" @default.
- NCIT_C104045 NCIT_P330 "701114" @default.
- NCIT_C104045 NCIT_P375 "ERK Inhibitor MK-8353" @default.
- NCIT_C104045 NCIT_P399 "701114" @default.
- NCIT_C104045 normalizedInformationContent "100" @default.
- NCIT_C104045 referenceCount "1" @default.
- NCIT_C104045 hasExactSynonym "ERK Inhibitor MK-8353" @default.
- NCIT_C104045 hasExactSynonym "MK-8353" @default.
- NCIT_C104045 hasExactSynonym "MK-8353-001" @default.
- NCIT_C104045 hasExactSynonym "SCH 900353" @default.
- NCIT_C104045 inSubset NCIT_C116977 @default.
- NCIT_C104045 inSubset NCIT_C116978 @default.
- NCIT_C104045 inSubset NCIT_C128784 @default.
- NCIT_C104045 inSubset NCIT_C157711 @default.
- NCIT_C104045 inSubset NCIT_C157712 @default.
- NCIT_C104045 inSubset NCIT_C176424 @default.
- NCIT_C104045 inSubset NCIT_C177537 @default.
- NCIT_C104045 type Class @default.
- NCIT_C104045 isDefinedBy ncit.owl @default.
- NCIT_C104045 label "ERK Inhibitor MK-8353" @default.
- NCIT_C104045 subClassOf NCIT_C104045 @default.
- NCIT_C104045 subClassOf NCIT_C129824 @default.
- NCIT_C104045 subClassOf NCIT_C129825 @default.
- NCIT_C104045 subClassOf NCIT_C1404 @default.
- NCIT_C104045 subClassOf NCIT_C174048 @default.
- NCIT_C104045 subClassOf NCIT_C1908 @default.
- NCIT_C104045 subClassOf NCIT_C1909 @default.
- NCIT_C104045 subClassOf NCIT_C2189 @default.
- NCIT_C104045 subClassOf NCIT_C274 @default.
- NCIT_C104045 subClassOf NCIT_C471 @default.
- NCIT_C104045 subClassOf NCIT_C61074 @default.