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- NCIT_C104048 IAO_0000115 "A proprietary oral formulation composed of the poorly soluble, synthetic triazole agent, itraconazole, dispersed in a polymer matrix, with antifungal and potential anti-angiogenic activities. Upon oral administration, itraconazole inhibits the enzyme cytochrome P450 lanosterol 14 alpha-demethylase, resulting in a decrease in fungal ergosterol synthesis. Although the exact mechanism through which itraconazole inhibits angiogenesis has yet to be fully elucidated, this agent appears to inhibit the Hedgehog (Hh) signaling pathway, cholesterol synthesis and mammalian target of rapamycin (mTOR) signaling in endothelial cells. This agent may also prevent the activation of and signaling by various angiogenic growth factors. By decreasing the tumor vasculature and nutrient supply, itraconazole ultimately inhibits tumor cell growth. The solid dispersion of itraconazole in the polymer matrix enhances dissolution of itraconazole in the gastrointestinal tract and increases its bioavailability; this allows for the administration of a much lower dose compared to itraconazole alone." @default.
- NCIT_C104048 NCIT_A32 NCIT_C1909 @default.
- NCIT_C104048 NCIT_NHC0 "C104048" @default.
- NCIT_C104048 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C104048 NCIT_P107 "Itraconazole Dispersion In Polymer Matrix" @default.
- NCIT_C104048 NCIT_P108 "Itraconazole Dispersion In Polymer Matrix" @default.
- NCIT_C104048 NCIT_P208 "CL439067" @default.
- NCIT_C104048 NCIT_P322 "CTRP" @default.
- NCIT_C104048 NCIT_P322 "GDC" @default.
- NCIT_C104048 NCIT_P329 "744267" @default.
- NCIT_C104048 NCIT_P330 "744267" @default.
- NCIT_C104048 NCIT_P375 "Itraconazole Dispersion In Polymer Matrix" @default.
- NCIT_C104048 NCIT_P399 "744267" @default.
- NCIT_C104048 normalizedInformationContent "100" @default.
- NCIT_C104048 referenceCount "1" @default.
- NCIT_C104048 hasExactSynonym "Itraconazole Dispersion In Polymer Matrix" @default.
- NCIT_C104048 hasExactSynonym "SUBA-Itraconazole" @default.
- NCIT_C104048 inSubset NCIT_C116977 @default.
- NCIT_C104048 inSubset NCIT_C116978 @default.
- NCIT_C104048 inSubset NCIT_C128784 @default.
- NCIT_C104048 inSubset NCIT_C157711 @default.
- NCIT_C104048 inSubset NCIT_C157712 @default.
- NCIT_C104048 inSubset NCIT_C176424 @default.
- NCIT_C104048 inSubset NCIT_C177537 @default.
- NCIT_C104048 type Class @default.
- NCIT_C104048 isDefinedBy ncit.owl @default.
- NCIT_C104048 label "Itraconazole Dispersion In Polymer Matrix" @default.
- NCIT_C104048 subClassOf NCIT_C104048 @default.
- NCIT_C104048 subClassOf NCIT_C1742 @default.
- NCIT_C104048 subClassOf NCIT_C1908 @default.
- NCIT_C104048 subClassOf NCIT_C1909 @default.
- NCIT_C104048 subClassOf NCIT_C254 @default.
- NCIT_C104048 subClassOf NCIT_C274 @default.
- NCIT_C104048 subClassOf NCIT_C514 @default.