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- NCIT_C104055 IAO_0000115 "The acetate form of the 21-substituted-19-nor-progestin telapristone, an orally available selective progesterone receptor modulator (SPRM), with potential anti-progesterone and antineoplastic activities. Upon oral administration, CDB-4124 competitively binds to the progesterone receptor (PR) in progesterone-responsive tissue and inhibits PR-mediated gene expression. This interferes with progesterone activity in the reproductive system. As a result, this agent may suppress ovulation and inhibit proliferation of endometrial tissue. Also, this agent may prevent cell growth and induce apoptosis in estrogen receptor (ER) and PR-positive breast cancer cells through a reduction in progesterone levels, ER downregulation and a suppression of the expression of cyclin-dependent kinases (CDK) 2 and 4, ultimately leading to G1/S cell cycle arrest. Unlike some other SPRMs, this agent does not exert any estrogenic, androgenic, anti-estrogenic, and anti-androgenic activities." @default.
- NCIT_C104055 NCIT_A32 NCIT_C1909 @default.
- NCIT_C104055 NCIT_A7 NCIT_C17075 @default.
- NCIT_C104055 NCIT_NHC0 "C104055" @default.
- NCIT_C104055 NCIT_P106 "Organic Chemical" @default.
- NCIT_C104055 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C104055 NCIT_P107 "Telapristone Acetate" @default.
- NCIT_C104055 NCIT_P108 "Telapristone Acetate" @default.
- NCIT_C104055 NCIT_P207 "C3501648" @default.
- NCIT_C104055 NCIT_P210 "198414-31-2" @default.
- NCIT_C104055 NCIT_P319 "1K9EYK92PQ" @default.
- NCIT_C104055 NCIT_P322 "CTRP" @default.
- NCIT_C104055 NCIT_P322 "FDA" @default.
- NCIT_C104055 NCIT_P322 "GDC" @default.
- NCIT_C104055 NCIT_P329 "598776" @default.
- NCIT_C104055 NCIT_P330 "598776" @default.
- NCIT_C104055 NCIT_P375 "Telapristone Acetate" @default.
- NCIT_C104055 NCIT_P399 "598776" @default.
- NCIT_C104055 normalizedInformationContent "100" @default.
- NCIT_C104055 referenceCount "1" @default.
- NCIT_C104055 hasExactSynonym "(8S,11R,13S,14S,17R)-11-(4-(Dimethylamino)phenyl)-17-(2-methoxyacetyl)-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl Acetate" @default.
- NCIT_C104055 hasExactSynonym "CDB-4124" @default.
- NCIT_C104055 hasExactSynonym "Proellex" @default.
- NCIT_C104055 hasExactSynonym "Progenta" @default.
- NCIT_C104055 hasExactSynonym "TELAPRISTONE ACETATE" @default.
- NCIT_C104055 hasExactSynonym "Telapristone Acetate" @default.
- NCIT_C104055 inSubset NCIT_C116977 @default.
- NCIT_C104055 inSubset NCIT_C116978 @default.
- NCIT_C104055 inSubset NCIT_C128784 @default.
- NCIT_C104055 inSubset NCIT_C157711 @default.
- NCIT_C104055 inSubset NCIT_C157712 @default.
- NCIT_C104055 inSubset NCIT_C176424 @default.
- NCIT_C104055 inSubset NCIT_C177537 @default.
- NCIT_C104055 inSubset NCIT_C63923 @default.
- NCIT_C104055 type Class @default.
- NCIT_C104055 isDefinedBy ncit.owl @default.
- NCIT_C104055 label "Telapristone Acetate" @default.
- NCIT_C104055 subClassOf NCIT_C104055 @default.
- NCIT_C104055 subClassOf NCIT_C147908 @default.
- NCIT_C104055 subClassOf NCIT_C1891 @default.
- NCIT_C104055 subClassOf NCIT_C1908 @default.
- NCIT_C104055 subClassOf NCIT_C1909 @default.
- NCIT_C104055 subClassOf NCIT_C547 @default.