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- NCIT_C104057 IAO_0000115 "An orally available 21-substituted-19-nor-progestin and selective progesterone receptor modulator (SPRM), with potential anti-progesterone and antineoplastic activities. Upon oral administration, telapristone competitively binds to the progesterone receptor (PR) in progesterone-responsive tissue and inhibits PR-mediated gene expression. This interferes with progesterone activity in the reproductive system. As a result, this agent may suppress ovulation and inhibit proliferation of endometrial tissue. Also, this agent may prevent cell growth and induce apoptosis in estrogen receptor (ER) and PR-positive breast cancer cells through a reduction in progesterone levels, ER downregulation and a suppression of the expression of cyclin-dependent kinases (CDK) 2 and 4, ultimately leading to G1/S cell cycle arrest. Unlike some other SPRMs, this agent does not exert any estrogenic, androgenic, anti-estrogenic, and anti-androgenic activities." @default.
- NCIT_C104057 NCIT_A32 NCIT_C1909 @default.
- NCIT_C104057 NCIT_NHC0 "C104057" @default.
- NCIT_C104057 NCIT_P106 "Organic Chemical" @default.
- NCIT_C104057 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C104057 NCIT_P108 "Telapristone" @default.
- NCIT_C104057 NCIT_P207 "C3641719" @default.
- NCIT_C104057 NCIT_P210 "198414-30-1" @default.
- NCIT_C104057 NCIT_P319 "65703MV349" @default.
- NCIT_C104057 NCIT_P322 "FDA" @default.
- NCIT_C104057 NCIT_P322 "GDC" @default.
- NCIT_C104057 NCIT_P375 "Telapristone" @default.
- NCIT_C104057 normalizedInformationContent "100" @default.
- NCIT_C104057 referenceCount "1" @default.
- NCIT_C104057 hasExactSynonym "11Beta-(4-(dimethylamino)phenyl)-17-hydroxy-21-methoxy-19- norpregna-4,9-diene-3,20-dione" @default.
- NCIT_C104057 hasExactSynonym "TELAPRISTONE" @default.
- NCIT_C104057 hasExactSynonym "Telapristone" @default.
- NCIT_C104057 inSubset NCIT_C128784 @default.
- NCIT_C104057 inSubset NCIT_C157711 @default.
- NCIT_C104057 inSubset NCIT_C157712 @default.
- NCIT_C104057 inSubset NCIT_C177537 @default.
- NCIT_C104057 inSubset NCIT_C63923 @default.
- NCIT_C104057 type Class @default.
- NCIT_C104057 isDefinedBy ncit.owl @default.
- NCIT_C104057 label "Telapristone" @default.
- NCIT_C104057 subClassOf NCIT_C104057 @default.
- NCIT_C104057 subClassOf NCIT_C147908 @default.
- NCIT_C104057 subClassOf NCIT_C1891 @default.
- NCIT_C104057 subClassOf NCIT_C1908 @default.
- NCIT_C104057 subClassOf NCIT_C1909 @default.
- NCIT_C104057 subClassOf NCIT_C547 @default.