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- NCIT_C104058 IAO_0000115 "An immunoconjugate containing a glycoengineered, humanized monoclonal antibody directed against the human epidermal growth factor receptor HER3 (ErbB3), with potential antineoplastic activity. Upon administration, lumretuzumab binds to the extracellular domain of HER3 and inhibits HER3 dimerization; thereby, preventing EGFR-dependent signaling. In addition, RO5479599 stimulates the immune system to exert antibody-dependent cellular cytotoxicity (ADCC). This may decrease proliferation of HER3-overexpressing tumor cells. HER3, a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases, is frequently overexpressed in tumors; it has no active kinase domain but is activated through heterodimerization with other members of the EGFR receptor family, such as HER2." @default.
- NCIT_C104058 NCIT_A32 NCIT_C1909 @default.
- NCIT_C104058 NCIT_NHC0 "C104058" @default.
- NCIT_C104058 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C104058 NCIT_P108 "Lumretuzumab" @default.
- NCIT_C104058 NCIT_P208 "CL433954" @default.
- NCIT_C104058 NCIT_P210 "1448327-63-6" @default.
- NCIT_C104058 NCIT_P319 "Y6M3205516" @default.
- NCIT_C104058 NCIT_P322 "FDA" @default.
- NCIT_C104058 NCIT_P322 "GDC" @default.
- NCIT_C104058 NCIT_P329 "744816" @default.
- NCIT_C104058 NCIT_P330 "744816" @default.
- NCIT_C104058 NCIT_P375 "Immunoconjugate RO5479599" @default.
- NCIT_C104058 NCIT_P375 "Lumretuzumab" @default.
- NCIT_C104058 NCIT_P399 "744816" @default.
- NCIT_C104058 NCIT_R124 NCIT_C17710 @default.
- NCIT_C104058 NCIT_R124 NCIT_C17828 @default.
- NCIT_C104058 NCIT_R124 NCIT_C18219 @default.
- NCIT_C104058 NCIT_R124 NCIT_C19986 @default.
- NCIT_C104058 NCIT_R124 NCIT_C40474 @default.
- NCIT_C104058 normalizedInformationContent "100" @default.
- NCIT_C104058 referenceCount "1" @default.
- NCIT_C104058 hasExactSynonym "LUMRETUZUMAB" @default.
- NCIT_C104058 hasExactSynonym "Lumretuzumab" @default.
- NCIT_C104058 hasExactSynonym "RO5479599" @default.
- NCIT_C104058 inSubset NCIT_C128784 @default.
- NCIT_C104058 inSubset NCIT_C157711 @default.
- NCIT_C104058 inSubset NCIT_C157712 @default.
- NCIT_C104058 inSubset NCIT_C176424 @default.
- NCIT_C104058 inSubset NCIT_C177537 @default.
- NCIT_C104058 inSubset NCIT_C63923 @default.
- NCIT_C104058 type Class @default.
- NCIT_C104058 isDefinedBy ncit.owl @default.
- NCIT_C104058 label "Lumretuzumab" @default.
- NCIT_C104058 subClassOf NCIT_C104058 @default.
- NCIT_C104058 subClassOf NCIT_C129821 @default.
- NCIT_C104058 subClassOf NCIT_C129822 @default.
- NCIT_C104058 subClassOf NCIT_C163758 @default.
- NCIT_C104058 subClassOf NCIT_C1908 @default.
- NCIT_C104058 subClassOf NCIT_C1909 @default.
- NCIT_C104058 subClassOf NCIT_C199383 @default.
- NCIT_C104058 subClassOf NCIT_C199386 @default.
- NCIT_C104058 subClassOf NCIT_C20401 @default.
- NCIT_C104058 subClassOf NCIT_C274 @default.
- NCIT_C104058 subClassOf NCIT_C307 @default.
- NCIT_C104058 subClassOf NCIT_C308 @default.