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- NCIT_C1041 IAO_0000115 "The hydrochloride salt of a semi-synthetic, beta-lactamase-resistant, fourth-generation cephalosporin antibiotic derived from an Acremonium fungal species with broad-spectrum bactericidal activity. Administered parenterally, cefepime inhibits bacterial cell wall synthesis by binding to and inactivating penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity, resulting in a reduction of bacterial cell wall stability and cell lysis. This agent is more active against a variety of Gram-positive pathogens compared to third-generation cephalosporins." @default.
- NCIT_C1041 NCIT_A6 NCIT_C65294 @default.
- NCIT_C1041 NCIT_NHC0 "C1041" @default.
- NCIT_C1041 NCIT_P106 "Antibiotic" @default.
- NCIT_C1041 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1041 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1041 NCIT_P107 "Cefepime Hydrochloride" @default.
- NCIT_C1041 NCIT_P108 "Cefepime Hydrochloride" @default.
- NCIT_C1041 NCIT_P207 "C0771284" @default.
- NCIT_C1041 NCIT_P210 "123171-59-5" @default.
- NCIT_C1041 NCIT_P302 "Upper respiratory tract and urinary tract infections; febrile neutropenic conditions" @default.
- NCIT_C1041 NCIT_P319 "I8X1O0607P" @default.
- NCIT_C1041 NCIT_P322 "CTRP" @default.
- NCIT_C1041 NCIT_P322 "FDA" @default.
- NCIT_C1041 NCIT_P329 "38350" @default.
- NCIT_C1041 NCIT_P330 "38350" @default.
- NCIT_C1041 NCIT_P350 "C19H24N6O5S2.2ClH.H2O" @default.
- NCIT_C1041 NCIT_P366 "Cefepime" @default.
- NCIT_C1041 NCIT_P368 "CHEBI:31368" @default.
- NCIT_C1041 NCIT_P399 "38350" @default.
- NCIT_C1041 normalizedInformationContent "100" @default.
- NCIT_C1041 referenceCount "1" @default.
- NCIT_C1041 hasExactSynonym "CEFEPIME HYDROCHLORIDE" @default.
- NCIT_C1041 hasExactSynonym "Cefepime Hydrochloride" @default.
- NCIT_C1041 hasExactSynonym "Maxipime" @default.
- NCIT_C1041 hasExactSynonym "Pyrrolidinium, 1-((7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-1-methyl-, hydroxide, inner salt, (6R-(6alpha,7beta(Z)))-" @default.
- NCIT_C1041 inSubset NCIT_C116977 @default.
- NCIT_C1041 inSubset NCIT_C116978 @default.
- NCIT_C1041 inSubset NCIT_C176424 @default.
- NCIT_C1041 inSubset NCIT_C63923 @default.
- NCIT_C1041 type Class @default.
- NCIT_C1041 isDefinedBy ncit.owl @default.
- NCIT_C1041 label "Cefepime Hydrochloride" @default.
- NCIT_C1041 subClassOf NCIT_C1041 @default.
- NCIT_C1041 subClassOf NCIT_C1908 @default.
- NCIT_C1041 subClassOf NCIT_C1909 @default.
- NCIT_C1041 subClassOf NCIT_C254 @default.
- NCIT_C1041 subClassOf NCIT_C258 @default.
- NCIT_C1041 subClassOf NCIT_C260 @default.
- NCIT_C1041 subClassOf NCIT_C357 @default.