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- NCIT_C104153 IAO_0000115 "An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against B-cell antigen receptor complex-associated protein beta chain (CD79B) conjugated, via a protease-cleavable peptide linker, to monomethyl auristatin E (MMAE), an auristatin derivative and a potent microtubule inhibitor, with potential antineoplastic activity. Upon administration, the monoclonal antibody moiety of polatuzumab vedotin selectively binds to CD79B, a protein which is abundantly expressed on the surface of B-cells. Upon internalization and proteolytic cleavage, MMAE binds to tubulin and inhibits its polymerization, resulting in G2/M phase arrest and tumor cell apoptosis. CD79B, a component of the B-cell receptor (BCR), plays a key role in B-cell receptor signaling and is expressed on the surface of almost all types of malignant B-cells." @default.
- NCIT_C104153 NCIT_A32 NCIT_C1909 @default.
- NCIT_C104153 NCIT_A7 NCIT_C97426 @default.
- NCIT_C104153 NCIT_NHC0 "C104153" @default.
- NCIT_C104153 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C104153 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C104153 NCIT_P107 "Polatuzumab Vedotin" @default.
- NCIT_C104153 NCIT_P108 "Polatuzumab Vedotin" @default.
- NCIT_C104153 NCIT_P207 "C4078806" @default.
- NCIT_C104153 NCIT_P210 "1313206-42-6" @default.
- NCIT_C104153 NCIT_P302 "relapsed or refractory diffuse large B-cell lymphoma (DLBCL)" @default.
- NCIT_C104153 NCIT_P319 "KG6VO684Z6" @default.
- NCIT_C104153 NCIT_P322 "CTRP" @default.
- NCIT_C104153 NCIT_P322 "FDA" @default.
- NCIT_C104153 NCIT_P322 "GDC" @default.
- NCIT_C104153 NCIT_P329 "695317" @default.
- NCIT_C104153 NCIT_P330 "695317" @default.
- NCIT_C104153 NCIT_P375 "Polatuzumab Vedotin" @default.
- NCIT_C104153 NCIT_P399 "695317" @default.
- NCIT_C104153 normalizedInformationContent "90.826665450122817" @default.
- NCIT_C104153 referenceCount "4" @default.
- NCIT_C104153 hasExactSynonym "ADC DCDS4501A" @default.
- NCIT_C104153 hasExactSynonym "Antibody-Drug Conjugate DCDS4501A" @default.
- NCIT_C104153 hasExactSynonym "DCDS4501A" @default.
- NCIT_C104153 hasExactSynonym "FCU 2711" @default.
- NCIT_C104153 hasExactSynonym "POLATUZUMAB VEDOTIN" @default.
- NCIT_C104153 hasExactSynonym "Polatuzumab Vedotin" @default.
- NCIT_C104153 hasExactSynonym "Polivy" @default.
- NCIT_C104153 hasExactSynonym "RG7596" @default.
- NCIT_C104153 hasExactSynonym "Ro 5541077-000" @default.
- NCIT_C104153 hasExactSynonym "polatuzumab vedotin-piiq" @default.
- NCIT_C104153 inSubset NCIT_C116977 @default.
- NCIT_C104153 inSubset NCIT_C116978 @default.
- NCIT_C104153 inSubset NCIT_C128784 @default.
- NCIT_C104153 inSubset NCIT_C157711 @default.
- NCIT_C104153 inSubset NCIT_C157712 @default.
- NCIT_C104153 inSubset NCIT_C176424 @default.
- NCIT_C104153 inSubset NCIT_C177537 @default.
- NCIT_C104153 inSubset NCIT_C63923 @default.
- NCIT_C104153 type Class @default.
- NCIT_C104153 isDefinedBy ncit.owl @default.
- NCIT_C104153 label "Polatuzumab Vedotin" @default.
- NCIT_C104153 subClassOf NCIT_C104153 @default.
- NCIT_C104153 subClassOf NCIT_C129821 @default.
- NCIT_C104153 subClassOf NCIT_C129823 @default.
- NCIT_C104153 subClassOf NCIT_C1512 @default.
- NCIT_C104153 subClassOf NCIT_C1908 @default.
- NCIT_C104153 subClassOf NCIT_C1909 @default.
- NCIT_C104153 subClassOf NCIT_C274 @default.
- NCIT_C104153 subClassOf NCIT_C307 @default.
- NCIT_C104153 subClassOf NCIT_C308 @default.