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- NCIT_C104260 IAO_0000115 "A human, recombinant monoclonal antibody (MoAb) against macrophage migration inhibitory factor (MIF), with potential immunomodulating, anti-inflammatory and antineoplastic activities. Upon intravenous administration, imalumab binds to MIF, blocking its activity and preventing the MIF-mediated secretion of certain cytokines, including interleukin-1 beta and tumor necrosis factor-alpha. This may lead to an inhibition of cancer cell proliferation in MIF-overexpressing tumor cells. MIF, a pro-inflammatory cytokine overexpressed in some cancers, plays a key role in inflammation, immune responses and cancer cell proliferation." @default.
- NCIT_C104260 NCIT_A32 NCIT_C1909 @default.
- NCIT_C104260 NCIT_A7 NCIT_C28467 @default.
- NCIT_C104260 NCIT_NHC0 "C104260" @default.
- NCIT_C104260 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C104260 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C104260 NCIT_P107 "Imalumab" @default.
- NCIT_C104260 NCIT_P108 "Imalumab" @default.
- NCIT_C104260 NCIT_P208 "CL446652" @default.
- NCIT_C104260 NCIT_P210 "1430205-07-4" @default.
- NCIT_C104260 NCIT_P319 "22F97PC79G" @default.
- NCIT_C104260 NCIT_P322 "CTRP" @default.
- NCIT_C104260 NCIT_P322 "FDA" @default.
- NCIT_C104260 NCIT_P322 "GDC" @default.
- NCIT_C104260 NCIT_P329 "740468" @default.
- NCIT_C104260 NCIT_P330 "740468" @default.
- NCIT_C104260 NCIT_P375 "Imalumab" @default.
- NCIT_C104260 NCIT_P399 "740468" @default.
- NCIT_C104260 NCIT_R124 NCIT_C17710 @default.
- NCIT_C104260 NCIT_R124 NCIT_C17828 @default.
- NCIT_C104260 NCIT_R124 NCIT_C18219 @default.
- NCIT_C104260 NCIT_R124 NCIT_C19986 @default.
- NCIT_C104260 NCIT_R124 NCIT_C40474 @default.
- NCIT_C104260 normalizedInformationContent "100" @default.
- NCIT_C104260 referenceCount "1" @default.
- NCIT_C104260 hasExactSynonym "BAX-69" @default.
- NCIT_C104260 hasExactSynonym "BAX069" @default.
- NCIT_C104260 hasExactSynonym "BAX69" @default.
- NCIT_C104260 hasExactSynonym "IMALUMAB" @default.
- NCIT_C104260 hasExactSynonym "Imalumab" @default.
- NCIT_C104260 hasExactSynonym "Immunoglobulin G1-kappa, Anti-(Homo sapiens MIF (Macrophage Migration Inhibitory Factor, Glycosylation-inhibiting Factor, GlIF, GIF)), Homo sapiens Monoclonal Antibody" @default.
- NCIT_C104260 inSubset NCIT_C116977 @default.
- NCIT_C104260 inSubset NCIT_C116978 @default.
- NCIT_C104260 inSubset NCIT_C128784 @default.
- NCIT_C104260 inSubset NCIT_C157711 @default.
- NCIT_C104260 inSubset NCIT_C157712 @default.
- NCIT_C104260 inSubset NCIT_C176424 @default.
- NCIT_C104260 inSubset NCIT_C177537 @default.
- NCIT_C104260 inSubset NCIT_C63923 @default.
- NCIT_C104260 type Class @default.
- NCIT_C104260 isDefinedBy ncit.owl @default.
- NCIT_C104260 label "Imalumab" @default.
- NCIT_C104260 subClassOf NCIT_C104260 @default.
- NCIT_C104260 subClassOf NCIT_C129821 @default.
- NCIT_C104260 subClassOf NCIT_C129822 @default.
- NCIT_C104260 subClassOf NCIT_C1908 @default.
- NCIT_C104260 subClassOf NCIT_C1909 @default.
- NCIT_C104260 subClassOf NCIT_C20401 @default.
- NCIT_C104260 subClassOf NCIT_C274 @default.
- NCIT_C104260 subClassOf NCIT_C307 @default.
- NCIT_C104260 subClassOf NCIT_C308 @default.