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- NCIT_C104267 IAO_0000115 "An orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with potential antineoplastic activity. Derazantinib binds to and potently inhibits the activity of FGFR subtypes 1, 2 and 3. This may result in the inhibition of FGFR-mediated signal transduction pathways, tumor cell proliferation, tumor angiogenesis and tumor cell death in FGFR-overexpressing tumor cells. FGFR, a receptor tyrosine kinase, is upregulated in many tumor cell types and plays a key role in tumor cellular proliferation, differentiation, angiogenesis and survival." @default.
- NCIT_C104267 NCIT_A32 NCIT_C1909 @default.
- NCIT_C104267 NCIT_A7 NCIT_C17297 @default.
- NCIT_C104267 NCIT_NHC0 "C104267" @default.
- NCIT_C104267 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C104267 NCIT_P107 "Derazantinib" @default.
- NCIT_C104267 NCIT_P108 "Derazantinib" @default.
- NCIT_C104267 NCIT_P208 "CL445613" @default.
- NCIT_C104267 NCIT_P210 "1234356-69-4" @default.
- NCIT_C104267 NCIT_P319 "N9B0H171MJ" @default.
- NCIT_C104267 NCIT_P322 "CTRP" @default.
- NCIT_C104267 NCIT_P322 "FDA" @default.
- NCIT_C104267 NCIT_P322 "GDC" @default.
- NCIT_C104267 NCIT_P329 "744652" @default.
- NCIT_C104267 NCIT_P330 "744652" @default.
- NCIT_C104267 NCIT_P368 "CHEBI:63453" @default.
- NCIT_C104267 NCIT_P375 "Derazantinib" @default.
- NCIT_C104267 NCIT_P399 "744652" @default.
- NCIT_C104267 normalizedInformationContent "100" @default.
- NCIT_C104267 referenceCount "1" @default.
- NCIT_C104267 hasExactSynonym "ARQ 087" @default.
- NCIT_C104267 hasExactSynonym "ARQ-087" @default.
- NCIT_C104267 hasExactSynonym "DERAZANTINIB" @default.
- NCIT_C104267 hasExactSynonym "Derazantinib" @default.
- NCIT_C104267 inSubset NCIT_C116977 @default.
- NCIT_C104267 inSubset NCIT_C116978 @default.
- NCIT_C104267 inSubset NCIT_C128784 @default.
- NCIT_C104267 inSubset NCIT_C157711 @default.
- NCIT_C104267 inSubset NCIT_C157712 @default.
- NCIT_C104267 inSubset NCIT_C176424 @default.
- NCIT_C104267 inSubset NCIT_C177537 @default.
- NCIT_C104267 inSubset NCIT_C63923 @default.
- NCIT_C104267 type Class @default.
- NCIT_C104267 isDefinedBy ncit.owl @default.
- NCIT_C104267 label "Derazantinib" @default.
- NCIT_C104267 subClassOf NCIT_C104267 @default.
- NCIT_C104267 subClassOf NCIT_C129824 @default.
- NCIT_C104267 subClassOf NCIT_C129825 @default.
- NCIT_C104267 subClassOf NCIT_C1404 @default.
- NCIT_C104267 subClassOf NCIT_C1908 @default.
- NCIT_C104267 subClassOf NCIT_C1909 @default.
- NCIT_C104267 subClassOf NCIT_C1967 @default.
- NCIT_C104267 subClassOf NCIT_C2189 @default.
- NCIT_C104267 subClassOf NCIT_C274 @default.
- NCIT_C104267 subClassOf NCIT_C471 @default.