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- NCIT_C104280 IAO_0000115 "An orally bioavailable HDM2 (human homolog of double minute 2) antagonist with potential antineoplastic activity. Upon oral administration, p53/HDM2 interaction inhibitor CGM097 inhibits the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction, the proteasome-mediated enzymatic degradation of p53 is inhibited, which may result in the restoration of p53 signaling and, thus, the p53-mediated induction of tumor cell apoptosis. HDM2, a zinc finger nuclear phosphoprotein, is a negative regulator of the p53 pathway, often overexpressed in cancer cells and has been implicated in cancer cell proliferation and survival." @default.
- NCIT_C104280 NCIT_A32 NCIT_C1909 @default.
- NCIT_C104280 NCIT_NHC0 "C104280" @default.
- NCIT_C104280 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C104280 NCIT_P107 "p53/HDM2 Interaction Inhibitor CGM097" @default.
- NCIT_C104280 NCIT_P108 "p53/HDM2 Interaction Inhibitor CGM097" @default.
- NCIT_C104280 NCIT_P207 "C3641742" @default.
- NCIT_C104280 NCIT_P210 "1313363-54-0" @default.
- NCIT_C104280 NCIT_P319 "4UF6MSL0ZH" @default.
- NCIT_C104280 NCIT_P322 "CTRP" @default.
- NCIT_C104280 NCIT_P322 "FDA" @default.
- NCIT_C104280 NCIT_P322 "GDC" @default.
- NCIT_C104280 NCIT_P329 "744999" @default.
- NCIT_C104280 NCIT_P330 "744999" @default.
- NCIT_C104280 NCIT_P375 "p53/HDM2 Interaction Inhibitor CGM097" @default.
- NCIT_C104280 NCIT_P399 "744999" @default.
- NCIT_C104280 normalizedInformationContent "100" @default.
- NCIT_C104280 referenceCount "1" @default.
- NCIT_C104280 hasExactSynonym "CGM-097" @default.
- NCIT_C104280 hasExactSynonym "CGM097" @default.
- NCIT_C104280 hasExactSynonym "HDM2/p53 Inhibitor CGM097" @default.
- NCIT_C104280 hasExactSynonym "p53/HDM2 Interaction Inhibitor CGM097" @default.
- NCIT_C104280 inSubset NCIT_C116977 @default.
- NCIT_C104280 inSubset NCIT_C116978 @default.
- NCIT_C104280 inSubset NCIT_C128784 @default.
- NCIT_C104280 inSubset NCIT_C157711 @default.
- NCIT_C104280 inSubset NCIT_C157712 @default.
- NCIT_C104280 inSubset NCIT_C176424 @default.
- NCIT_C104280 inSubset NCIT_C177537 @default.
- NCIT_C104280 inSubset NCIT_C63923 @default.
- NCIT_C104280 type Class @default.
- NCIT_C104280 isDefinedBy ncit.owl @default.
- NCIT_C104280 label "p53/HDM2 Interaction Inhibitor CGM097" @default.
- NCIT_C104280 subClassOf NCIT_C104280 @default.
- NCIT_C104280 subClassOf NCIT_C129839 @default.
- NCIT_C104280 subClassOf NCIT_C162996 @default.
- NCIT_C104280 subClassOf NCIT_C1908 @default.
- NCIT_C104280 subClassOf NCIT_C1909 @default.
- NCIT_C104280 subClassOf NCIT_C274 @default.