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- NCIT_C104291 IAO_0000115 "A humanized monoclonal antibody against human tissue factor (TF), with potential antiangiogenic, anticoagulant and anti-inflammatory activities. Upon administration, anti-TF monoclonal antibody MORAb-066 binds to TF and prevents Factor VIIa (FVIIa) from binding, thereby interfering with the activation of Factor X (FX) into FXa. This may prevent thrombin formation and cancer-associated venous thromboembolism, and may inhibit angiogenesis and tumor cell proliferation. TF, a transmembrane protein and initiator of the coagulation cascade, is overexpressed in many tumor cells and tumor endothelial cells; its expression is correlated with metastasis, angiogenesis, tumor cell growth and tumor-associated thrombosis." @default.
- NCIT_C104291 NCIT_A32 NCIT_C1909 @default.
- NCIT_C104291 NCIT_NHC0 "C104291" @default.
- NCIT_C104291 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C104291 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C104291 NCIT_P107 "Anti-Tissue Factor Monoclonal Antibody MORAb-066" @default.
- NCIT_C104291 NCIT_P108 "Anti-Tissue Factor Monoclonal Antibody MORAb-066" @default.
- NCIT_C104291 NCIT_P208 "CL445626" @default.
- NCIT_C104291 NCIT_P322 "CTRP" @default.
- NCIT_C104291 NCIT_P322 "GDC" @default.
- NCIT_C104291 NCIT_P329 "745031" @default.
- NCIT_C104291 NCIT_P330 "745031" @default.
- NCIT_C104291 NCIT_P375 "Anti-Tissue Factor Monoclonal Antibody MORAb-066" @default.
- NCIT_C104291 NCIT_P399 "745031" @default.
- NCIT_C104291 NCIT_R124 NCIT_C17710 @default.
- NCIT_C104291 NCIT_R124 NCIT_C17828 @default.
- NCIT_C104291 NCIT_R124 NCIT_C18219 @default.
- NCIT_C104291 NCIT_R124 NCIT_C19986 @default.
- NCIT_C104291 NCIT_R124 NCIT_C40474 @default.
- NCIT_C104291 normalizedInformationContent "100" @default.
- NCIT_C104291 referenceCount "1" @default.
- NCIT_C104291 hasExactSynonym "Anti-TF Monoclonal Antibody MORAb-066" @default.
- NCIT_C104291 hasExactSynonym "Anti-Tissue Factor Monoclonal Antibody MORAb-066" @default.
- NCIT_C104291 hasExactSynonym "MORAb-066" @default.
- NCIT_C104291 inSubset NCIT_C116977 @default.
- NCIT_C104291 inSubset NCIT_C116978 @default.
- NCIT_C104291 inSubset NCIT_C128784 @default.
- NCIT_C104291 inSubset NCIT_C157711 @default.
- NCIT_C104291 inSubset NCIT_C157712 @default.
- NCIT_C104291 inSubset NCIT_C176424 @default.
- NCIT_C104291 inSubset NCIT_C177537 @default.
- NCIT_C104291 type Class @default.
- NCIT_C104291 isDefinedBy ncit.owl @default.
- NCIT_C104291 label "Anti-Tissue Factor Monoclonal Antibody MORAb-066" @default.
- NCIT_C104291 subClassOf NCIT_C104291 @default.
- NCIT_C104291 subClassOf NCIT_C129821 @default.
- NCIT_C104291 subClassOf NCIT_C129822 @default.
- NCIT_C104291 subClassOf NCIT_C1742 @default.
- NCIT_C104291 subClassOf NCIT_C1908 @default.
- NCIT_C104291 subClassOf NCIT_C1909 @default.
- NCIT_C104291 subClassOf NCIT_C20401 @default.
- NCIT_C104291 subClassOf NCIT_C274 @default.
- NCIT_C104291 subClassOf NCIT_C307 @default.
- NCIT_C104291 subClassOf NCIT_C308 @default.