Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C104292> ?p ?o ?g. }
Showing items 1 to 53 of
53
with 100 items per page.
- NCIT_C104292 IAO_0000115 "An orally bioavailable inhibitor of phosphoinositide 3-kinase (PI3K), mammalian target of rapamycin (mTOR), activin receptor-like kinase 1 (ALK-1) and DNA-dependent protein kinase (DNA-PK), with potential anti-angiogenic and antineoplastic activities. Upon oral administration, panulisib inhibits the activity of all four kinases. This prevents PI3K/mTOR and ALK-1-mediated signaling pathways and may lead to the inhibition of cancer cell growth in PI3K/mTOR-overexpressing tumor cells and angiogenesis in ALK-1-overexpressing endothelial cells. Also, by inhibiting DNA-PK, this agent inhibits the ability of tumor cells to repair damaged DNA. The PI3K/mTOR pathway is upregulated in a variety of tumors and plays an important role in regulating cancer cell proliferation, growth, and survival. ALK-1, a member of the transforming growth factor beta (TGF-b) type I receptor family, is overexpressed on endothelial cells in a variety of tumor types and increases endothelial cell proliferation and migration. DNA-PK is activated upon DNA damage and plays a key role in repairing double-stranded DNA breaks." @default.
- NCIT_C104292 NCIT_A32 NCIT_C1909 @default.
- NCIT_C104292 NCIT_A7 NCIT_C17270 @default.
- NCIT_C104292 NCIT_NHC0 "C104292" @default.
- NCIT_C104292 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C104292 NCIT_P107 "Panulisib" @default.
- NCIT_C104292 NCIT_P108 "Panulisib" @default.
- NCIT_C104292 NCIT_P208 "CL445627" @default.
- NCIT_C104292 NCIT_P210 "1356033-60-7" @default.
- NCIT_C104292 NCIT_P319 "S9WA04F921" @default.
- NCIT_C104292 NCIT_P322 "CTRP" @default.
- NCIT_C104292 NCIT_P322 "FDA" @default.
- NCIT_C104292 NCIT_P322 "GDC" @default.
- NCIT_C104292 NCIT_P329 "745036" @default.
- NCIT_C104292 NCIT_P330 "745036" @default.
- NCIT_C104292 NCIT_P375 "PI3K/mTOR/ALK-1/DNA-PK Inhibitor P7170" @default.
- NCIT_C104292 NCIT_P375 "Panulisib" @default.
- NCIT_C104292 NCIT_P399 "745036" @default.
- NCIT_C104292 normalizedInformationContent "100" @default.
- NCIT_C104292 referenceCount "1" @default.
- NCIT_C104292 hasExactSynonym "AK15176" @default.
- NCIT_C104292 hasExactSynonym "P7170" @default.
- NCIT_C104292 hasExactSynonym "PANULISIB" @default.
- NCIT_C104292 hasExactSynonym "PI3K/mTOR/ALK-1/DNA-PK Inhibitor P7170" @default.
- NCIT_C104292 hasExactSynonym "Panulisib" @default.
- NCIT_C104292 inSubset NCIT_C116977 @default.
- NCIT_C104292 inSubset NCIT_C116978 @default.
- NCIT_C104292 inSubset NCIT_C128784 @default.
- NCIT_C104292 inSubset NCIT_C157711 @default.
- NCIT_C104292 inSubset NCIT_C157712 @default.
- NCIT_C104292 inSubset NCIT_C176424 @default.
- NCIT_C104292 inSubset NCIT_C177537 @default.
- NCIT_C104292 inSubset NCIT_C63923 @default.
- NCIT_C104292 type Class @default.
- NCIT_C104292 isDefinedBy ncit.owl @default.
- NCIT_C104292 label "Panulisib" @default.
- NCIT_C104292 subClassOf NCIT_C104292 @default.
- NCIT_C104292 subClassOf NCIT_C129824 @default.
- NCIT_C104292 subClassOf NCIT_C129825 @default.
- NCIT_C104292 subClassOf NCIT_C1404 @default.
- NCIT_C104292 subClassOf NCIT_C141136 @default.
- NCIT_C104292 subClassOf NCIT_C163758 @default.
- NCIT_C104292 subClassOf NCIT_C1742 @default.
- NCIT_C104292 subClassOf NCIT_C1908 @default.
- NCIT_C104292 subClassOf NCIT_C1909 @default.
- NCIT_C104292 subClassOf NCIT_C192218 @default.
- NCIT_C104292 subClassOf NCIT_C1967 @default.
- NCIT_C104292 subClassOf NCIT_C2152 @default.
- NCIT_C104292 subClassOf NCIT_C2189 @default.
- NCIT_C104292 subClassOf NCIT_C2201 @default.
- NCIT_C104292 subClassOf NCIT_C274 @default.
- NCIT_C104292 subClassOf NCIT_C471 @default.
- NCIT_C104292 subClassOf NCIT_C61074 @default.