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- NCIT_C104413 IAO_0000115 "An orally bioavailable, selective inhibitor of the delta isoform of the 110 kDa catalytic subunit of class I phosphoinositide-3 kinases (PI3K) with potential antineoplastic activity. PI3K-delta inhibitor TGR-1202 inhibits PI3K and prevents the activation of the PI3K/AKT kinase signaling pathway. This decreases proliferation and induces cell death in susceptible tumor cells. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in tumor cells and cells of the hematopoietic lineage. The targeted inhibition of PI3K-delta allows for PI3K signaling in normal, non-neoplastic cells. PI3K, an enzyme often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival." @default.
- NCIT_C104413 NCIT_A32 NCIT_C1909 @default.
- NCIT_C104413 NCIT_A7 NCIT_C113631 @default.
- NCIT_C104413 NCIT_NHC0 "C104413" @default.
- NCIT_C104413 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C104413 NCIT_P107 "Umbralisib" @default.
- NCIT_C104413 NCIT_P108 "Umbralisib" @default.
- NCIT_C104413 NCIT_P208 "CL445680" @default.
- NCIT_C104413 NCIT_P210 "1532533-67-7" @default.
- NCIT_C104413 NCIT_P319 "38073MQB2A" @default.
- NCIT_C104413 NCIT_P322 "CTRP" @default.
- NCIT_C104413 NCIT_P322 "FDA" @default.
- NCIT_C104413 NCIT_P322 "GDC" @default.
- NCIT_C104413 NCIT_P375 "Umbralisib" @default.
- NCIT_C104413 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C104413 referenceCount "2" @default.
- NCIT_C104413 hasExactSynonym "2-((1S)-1-(4-Amino-3-(3-fluoro-4-(1-methylethoxy)phenyl)-1H-pyrazolo(3,4-d)pyrimidin-1-yl)ethyl)-6-fluoro-3-(3-fluorophenyl)-4H-1-benzopyran-4-one" @default.
- NCIT_C104413 hasExactSynonym "RP-5264" @default.
- NCIT_C104413 hasExactSynonym "RP5264" @default.
- NCIT_C104413 hasExactSynonym "TGR-1202" @default.
- NCIT_C104413 hasExactSynonym "UMBRALISIB" @default.
- NCIT_C104413 hasExactSynonym "Umbralisib" @default.
- NCIT_C104413 inSubset NCIT_C116977 @default.
- NCIT_C104413 inSubset NCIT_C116978 @default.
- NCIT_C104413 inSubset NCIT_C128784 @default.
- NCIT_C104413 inSubset NCIT_C157711 @default.
- NCIT_C104413 inSubset NCIT_C157712 @default.
- NCIT_C104413 inSubset NCIT_C176424 @default.
- NCIT_C104413 inSubset NCIT_C177537 @default.
- NCIT_C104413 inSubset NCIT_C63923 @default.
- NCIT_C104413 type Class @default.
- NCIT_C104413 isDefinedBy ncit.owl @default.
- NCIT_C104413 label "Umbralisib" @default.
- NCIT_C104413 subClassOf NCIT_C104413 @default.
- NCIT_C104413 subClassOf NCIT_C129824 @default.
- NCIT_C104413 subClassOf NCIT_C129825 @default.
- NCIT_C104413 subClassOf NCIT_C1404 @default.
- NCIT_C104413 subClassOf NCIT_C163758 @default.
- NCIT_C104413 subClassOf NCIT_C1742 @default.
- NCIT_C104413 subClassOf NCIT_C1908 @default.
- NCIT_C104413 subClassOf NCIT_C1909 @default.
- NCIT_C104413 subClassOf NCIT_C2152 @default.
- NCIT_C104413 subClassOf NCIT_C2189 @default.
- NCIT_C104413 subClassOf NCIT_C274 @default.
- NCIT_C104413 subClassOf NCIT_C471 @default.