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- NCIT_C104414 IAO_0000115 "A substance that inhibits protein geranylgeranyltransferase type 1 (GGTase-I), with potential antineoplastic activity. GGTase-I is involved in the posttranslational modification of a number of oncogenic GTPases, including K-Ras, N-Ras, RhoA, RhoC, Cdc42, RalA, RalB and Rac1. Inhibition of the prenylation of these oncogenic proteins inhibits both their oncogenic activity and membrane localization. This may result in cell cycle arrest and apoptosis. Protein geranylgeranylation, catayzed by GGTase-I, plays a critical role in malignant transformation and cancer cell proliferation, migration and invasion." @default.
- NCIT_C104414 NCIT_A32 NCIT_C1909 @default.
- NCIT_C104414 NCIT_A7 NCIT_C41056 @default.
- NCIT_C104414 NCIT_NHC0 "C104414" @default.
- NCIT_C104414 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C104414 NCIT_P107 "Geranylgeranyltransferase I Inhibitor" @default.
- NCIT_C104414 NCIT_P108 "Geranylgeranyltransferase I Inhibitor" @default.
- NCIT_C104414 NCIT_P208 "CL445681" @default.
- NCIT_C104414 NCIT_P322 "CTRP" @default.
- NCIT_C104414 NCIT_P322 "GDC" @default.
- NCIT_C104414 NCIT_P329 "745403" @default.
- NCIT_C104414 NCIT_P330 "745403" @default.
- NCIT_C104414 NCIT_P375 "Geranylgeranyltransferase I Inhibitor" @default.
- NCIT_C104414 NCIT_P399 "745403" @default.
- NCIT_C104414 normalizedInformationContent "100" @default.
- NCIT_C104414 referenceCount "1" @default.
- NCIT_C104414 hasExactSynonym "GGTI-I" @default.
- NCIT_C104414 hasExactSynonym "GGTase-I Inhibitor" @default.
- NCIT_C104414 hasExactSynonym "Geranylgeranyltransferase I Inhibitor" @default.
- NCIT_C104414 inSubset NCIT_C116977 @default.
- NCIT_C104414 inSubset NCIT_C116978 @default.
- NCIT_C104414 inSubset NCIT_C128784 @default.
- NCIT_C104414 inSubset NCIT_C157711 @default.
- NCIT_C104414 inSubset NCIT_C157712 @default.
- NCIT_C104414 inSubset NCIT_C176424 @default.
- NCIT_C104414 inSubset NCIT_C177537 @default.
- NCIT_C104414 type Class @default.
- NCIT_C104414 isDefinedBy ncit.owl @default.
- NCIT_C104414 label "Geranylgeranyltransferase I Inhibitor" @default.
- NCIT_C104414 subClassOf NCIT_C104414 @default.
- NCIT_C104414 subClassOf NCIT_C1908 @default.
- NCIT_C104414 subClassOf NCIT_C1909 @default.
- NCIT_C104414 subClassOf NCIT_C471 @default.