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- NCIT_C104731 IAO_0000115 "A radioconjugate composed of the cytokine interleukin-2 (IL-2) conjugated to the bifunctional chelating agent succinimidyl-6-hydrazinopyridine-3-carboxylate (HYNIC-NHS) and co-ligand tricine and labeled with the radioisotope technetium Tc 99m (99mTc-HYNIC-IL2), that can potentially be used as a diagnostic agent to detect tumor inflammation. Upon intravenous administration, IL-2 selectively binds to the IL-2 receptor (IL-2R) expressed on tumor infiltrating lymphocytes (TILs); upon internalization, the Tc99m moiety can be visualized using radioimaging, which allows the quantification of TILs expressing IL-2R. This agent detects tumor enlargement due to invasion by TILs and not tumor progression." @default.
- NCIT_C104731 NCIT_A7 NCIT_C104679 @default.
- NCIT_C104731 NCIT_NHC0 "C104731" @default.
- NCIT_C104731 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C104731 NCIT_P107 "Technetium Tc 99 Hydrazinonicotinamide-Tricine-linked Interleukin-2" @default.
- NCIT_C104731 NCIT_P108 "Technetium Tc 99 Hydrazinonicotinamide-Tricine-linked Interleukin-2" @default.
- NCIT_C104731 NCIT_P208 "CL445806" @default.
- NCIT_C104731 NCIT_P322 "CTRP" @default.
- NCIT_C104731 NCIT_P329 "745755" @default.
- NCIT_C104731 NCIT_P330 "745755" @default.
- NCIT_C104731 NCIT_P399 "745755" @default.
- NCIT_C104731 normalizedInformationContent "100" @default.
- NCIT_C104731 referenceCount "1" @default.
- NCIT_C104731 hasExactSynonym "99mTc-HYNIC-IL2" @default.
- NCIT_C104731 hasExactSynonym "Technetium Tc 99 Hydrazinonicotinamide-Tricine-linked Interleukin-2" @default.
- NCIT_C104731 inSubset NCIT_C116977 @default.
- NCIT_C104731 inSubset NCIT_C116978 @default.
- NCIT_C104731 inSubset NCIT_C176424 @default.
- NCIT_C104731 type Class @default.
- NCIT_C104731 isDefinedBy ncit.owl @default.
- NCIT_C104731 label "Technetium Tc 99 Hydrazinonicotinamide-Tricine-linked Interleukin-2" @default.
- NCIT_C104731 subClassOf NCIT_C104731 @default.
- NCIT_C104731 subClassOf NCIT_C1446 @default.
- NCIT_C104731 subClassOf NCIT_C1908 @default.
- NCIT_C104731 subClassOf NCIT_C1909 @default.
- NCIT_C104731 subClassOf NCIT_C2124 @default.