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- NCIT_C104732 IAO_0000115 "An orally bioavailable inhibitor of the c-Met receptor tyrosine kinase with potential antineoplastic activity. Savolitinib selectively binds to and inhibits the activation of c-Met in an ATP-competitive manner, and disrupts c-Met signal transduction pathways. This may result in cell growth inhibition in tumors that overexpress the c-Met protein. C-Met encodes the hepatocyte growth factor receptor tyrosine kinase and plays an important role in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis; this protein is overexpressed or mutated in a variety of cancers." @default.
- NCIT_C104732 NCIT_A32 NCIT_C1909 @default.
- NCIT_C104732 NCIT_NHC0 "C104732" @default.
- NCIT_C104732 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C104732 NCIT_P108 "Savolitinib" @default.
- NCIT_C104732 NCIT_P207 "C3642466" @default.
- NCIT_C104732 NCIT_P210 "1313725-88-0" @default.
- NCIT_C104732 NCIT_P319 "2A2DA6857R" @default.
- NCIT_C104732 NCIT_P322 "FDA" @default.
- NCIT_C104732 NCIT_P322 "GDC" @default.
- NCIT_C104732 NCIT_P329 "745761" @default.
- NCIT_C104732 NCIT_P330 "745761" @default.
- NCIT_C104732 NCIT_P375 "Savolitinib" @default.
- NCIT_C104732 NCIT_P399 "745761" @default.
- NCIT_C104732 normalizedInformationContent "100" @default.
- NCIT_C104732 referenceCount "1" @default.
- NCIT_C104732 hasExactSynonym "AZD 6094" @default.
- NCIT_C104732 hasExactSynonym "AZD6094" @default.
- NCIT_C104732 hasExactSynonym "HMPL-504" @default.
- NCIT_C104732 hasExactSynonym "SAVOLITINIB" @default.
- NCIT_C104732 hasExactSynonym "Savolitinib" @default.
- NCIT_C104732 hasExactSynonym "Volitinib" @default.
- NCIT_C104732 inSubset NCIT_C128784 @default.
- NCIT_C104732 inSubset NCIT_C157711 @default.
- NCIT_C104732 inSubset NCIT_C157712 @default.
- NCIT_C104732 inSubset NCIT_C176424 @default.
- NCIT_C104732 inSubset NCIT_C177537 @default.
- NCIT_C104732 inSubset NCIT_C63923 @default.
- NCIT_C104732 type Class @default.
- NCIT_C104732 isDefinedBy ncit.owl @default.
- NCIT_C104732 label "Savolitinib" @default.
- NCIT_C104732 subClassOf NCIT_C104732 @default.
- NCIT_C104732 subClassOf NCIT_C129824 @default.
- NCIT_C104732 subClassOf NCIT_C129825 @default.
- NCIT_C104732 subClassOf NCIT_C1404 @default.
- NCIT_C104732 subClassOf NCIT_C1742 @default.
- NCIT_C104732 subClassOf NCIT_C1908 @default.
- NCIT_C104732 subClassOf NCIT_C1909 @default.
- NCIT_C104732 subClassOf NCIT_C1967 @default.
- NCIT_C104732 subClassOf NCIT_C2189 @default.
- NCIT_C104732 subClassOf NCIT_C274 @default.
- NCIT_C104732 subClassOf NCIT_C471 @default.