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- NCIT_C104737 IAO_0000115 "A synthetic peptide vaccine consisting of a HLA-DRw53-restricted human Wilms' Tumor protein-1 (WT1) peptide comprised of amino acids 247 through 261, a HLA class II-restricted WT1 peptide, with potential immunomodulating and antitumor activities. Vaccination with WT1 247-261 peptide may stimulate a CD4-positive helper T-lymphocyte-mediated immune response against WT1 expressing cells. Activated helper T-cells stimulate dendritic cells, and activate the proliferation of other T-lymphoctes and B-lymphocytes. This causes tumor cell lysis and inhibition of cancer cell proliferation in WT1-overexpressing tumor cells. WT1, a zinc finger DNA-binding protein, is overexpressed in most types of leukemia and in a variety of solid cancers." @default.
- NCIT_C104737 NCIT_A7 NCIT_C17549 @default.
- NCIT_C104737 NCIT_NHC0 "C104737" @default.
- NCIT_C104737 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C104737 NCIT_P107 "WT1 247-261 Peptide Vaccine" @default.
- NCIT_C104737 NCIT_P108 "WT1 247-261 Peptide Vaccine" @default.
- NCIT_C104737 NCIT_P208 "CL445810" @default.
- NCIT_C104737 NCIT_P322 "CTRP" @default.
- NCIT_C104737 NCIT_P329 "746009" @default.
- NCIT_C104737 NCIT_P330 "746009" @default.
- NCIT_C104737 NCIT_P399 "746009" @default.
- NCIT_C104737 NCIT_R124 NCIT_C17828 @default.
- NCIT_C104737 NCIT_R124 NCIT_C17930 @default.
- NCIT_C104737 NCIT_R124 NCIT_C17937 @default.
- NCIT_C104737 NCIT_R124 NCIT_C18839 @default.
- NCIT_C104737 NCIT_R124 NCIT_C21124 @default.
- NCIT_C104737 NCIT_R124 NCIT_C45548 @default.
- NCIT_C104737 normalizedInformationContent "100" @default.
- NCIT_C104737 referenceCount "1" @default.
- NCIT_C104737 hasExactSynonym "WT1 247-261 Peptide Vaccine" @default.
- NCIT_C104737 inSubset NCIT_C116977 @default.
- NCIT_C104737 inSubset NCIT_C116978 @default.
- NCIT_C104737 inSubset NCIT_C128784 @default.
- NCIT_C104737 inSubset NCIT_C176424 @default.
- NCIT_C104737 type Class @default.
- NCIT_C104737 isDefinedBy ncit.owl @default.
- NCIT_C104737 label "WT1 247-261 Peptide Vaccine" @default.
- NCIT_C104737 subClassOf NCIT_C104737 @default.
- NCIT_C104737 subClassOf NCIT_C129820 @default.
- NCIT_C104737 subClassOf NCIT_C1663 @default.
- NCIT_C104737 subClassOf NCIT_C1752 @default.
- NCIT_C104737 subClassOf NCIT_C1908 @default.
- NCIT_C104737 subClassOf NCIT_C1909 @default.
- NCIT_C104737 subClassOf NCIT_C274 @default.
- NCIT_C104737 subClassOf NCIT_C307 @default.
- NCIT_C104737 subClassOf NCIT_C308 @default.
- NCIT_C104737 subClassOf NCIT_C923 @default.