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- NCIT_C104743 IAO_0000115 "A non-replicating recombinant adenovirus type 5 (Ad5)-vector encoding the gene for interferon alpha-2b (IFN alpha-2b) and the gene transfer enhancement agent Syn 3, with potential antineoplastic activity. Upon intravesical administration, nadofaragene firadenovec/Syn3 transfects both cancerous and normal bladder cells, and the adenovirus secretes interferon (IFN alpha-2b) into the bladder. IFN exerts a direct antitumor killing effect and a bystander effect, thereby killing adjacent, non-transfected cancerous bladder cells. Syn 3 enhances the ability of the adenoviral vector to transfect cells." @default.
- NCIT_C104743 NCIT_NHC0 "C104743" @default.
- NCIT_C104743 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C104743 NCIT_P108 "Nadofaragene Firadenovec/Syn3" @default.
- NCIT_C104743 NCIT_P200 "C1962" @default.
- NCIT_C104743 NCIT_P200 "C49146" @default.
- NCIT_C104743 NCIT_P208 "CL445814" @default.
- NCIT_C104743 NCIT_P310 "Retired_Concept" @default.
- NCIT_C104743 NCIT_P98 "Tue Aug 08 12:29:11 EDT 2023 - See 'Nadofaragene Firadenovec(C71011)'" @default.
- NCIT_C104743 normalizedInformationContent "100" @default.
- NCIT_C104743 referenceCount "1" @default.
- NCIT_C104743 hasExactSynonym "Nadofaragene Firadenovec/Syn3" @default.
- NCIT_C104743 type Class @default.
- NCIT_C104743 isDefinedBy ncit.owl @default.
- NCIT_C104743 label "Nadofaragene Firadenovec/Syn3" @default.
- NCIT_C104743 subClassOf NCIT_C104743 @default.
- NCIT_C104743 subClassOf NCIT_C28428 @default.
- NCIT_C104743 subClassOf NCIT_C83485 @default.
- NCIT_C104743 deprecated "true" @default.