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- NCIT_C104744 IAO_0000115 "An orally available inhibitor of extracellular signal-regulated kinase (ERK) 1 and 2, with potential antineoplastic activity. Upon oral administration, ulixertinib inhibits both ERK 1 and 2, thereby preventing the activation of ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is often upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival." @default.
- NCIT_C104744 NCIT_A32 NCIT_C1909 @default.
- NCIT_C104744 NCIT_A7 NCIT_C17408 @default.
- NCIT_C104744 NCIT_A7 NCIT_C17589 @default.
- NCIT_C104744 NCIT_NHC0 "C104744" @default.
- NCIT_C104744 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C104744 NCIT_P107 "Ulixertinib" @default.
- NCIT_C104744 NCIT_P108 "Ulixertinib" @default.
- NCIT_C104744 NCIT_P208 "CL445815" @default.
- NCIT_C104744 NCIT_P210 "869886-67-9" @default.
- NCIT_C104744 NCIT_P319 "16ZDH50O1U" @default.
- NCIT_C104744 NCIT_P322 "CTRP" @default.
- NCIT_C104744 NCIT_P322 "FDA" @default.
- NCIT_C104744 NCIT_P322 "GDC" @default.
- NCIT_C104744 NCIT_P329 "746054" @default.
- NCIT_C104744 NCIT_P330 "746054" @default.
- NCIT_C104744 NCIT_P375 "Ulixertinib" @default.
- NCIT_C104744 NCIT_P399 "746054" @default.
- NCIT_C104744 normalizedInformationContent "100" @default.
- NCIT_C104744 referenceCount "1" @default.
- NCIT_C104744 hasExactSynonym "1H-Pyrrole-2-carboxamide, 4-(5-chloro-2-((1-methylethyl)amino)-4-pyridinyl)-N-((1S)-1-(3-chlorophenyl)-2-hydroxyethyl)-" @default.
- NCIT_C104744 hasExactSynonym "BVD-523" @default.
- NCIT_C104744 hasExactSynonym "ULIXERTINIB" @default.
- NCIT_C104744 hasExactSynonym "Ulixertinib" @default.
- NCIT_C104744 hasExactSynonym "VRT752271" @default.
- NCIT_C104744 inSubset NCIT_C116977 @default.
- NCIT_C104744 inSubset NCIT_C116978 @default.
- NCIT_C104744 inSubset NCIT_C128784 @default.
- NCIT_C104744 inSubset NCIT_C157711 @default.
- NCIT_C104744 inSubset NCIT_C157712 @default.
- NCIT_C104744 inSubset NCIT_C176424 @default.
- NCIT_C104744 inSubset NCIT_C177537 @default.
- NCIT_C104744 inSubset NCIT_C63923 @default.
- NCIT_C104744 type Class @default.
- NCIT_C104744 isDefinedBy ncit.owl @default.
- NCIT_C104744 label "Ulixertinib" @default.
- NCIT_C104744 subClassOf NCIT_C104744 @default.
- NCIT_C104744 subClassOf NCIT_C129824 @default.
- NCIT_C104744 subClassOf NCIT_C129825 @default.
- NCIT_C104744 subClassOf NCIT_C1404 @default.
- NCIT_C104744 subClassOf NCIT_C1908 @default.
- NCIT_C104744 subClassOf NCIT_C1909 @default.
- NCIT_C104744 subClassOf NCIT_C2189 @default.
- NCIT_C104744 subClassOf NCIT_C274 @default.
- NCIT_C104744 subClassOf NCIT_C471 @default.
- NCIT_C104744 subClassOf NCIT_C61074 @default.