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- NCIT_C104746 IAO_0000115 "An orally bioavailable inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. IGF-1R inhibitor PL225B selectively binds to and inhibits the activities of IGF-1R, which may result in both the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis in IGF-1R-overexpressing tumor cells. IGF-1R, a receptor tyrosine kinase overexpressed in a variety of human cancers, plays a significant role in the stimulation of cellular proliferation, oncogenic transformation, and suppression of apoptosis." @default.
- NCIT_C104746 NCIT_A32 NCIT_C1909 @default.
- NCIT_C104746 NCIT_A7 NCIT_C17531 @default.
- NCIT_C104746 NCIT_NHC0 "C104746" @default.
- NCIT_C104746 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C104746 NCIT_P107 "IGF-1R Inhibitor PL225B" @default.
- NCIT_C104746 NCIT_P108 "IGF-1R Inhibitor PL225B" @default.
- NCIT_C104746 NCIT_P208 "CL445817" @default.
- NCIT_C104746 NCIT_P322 "CTRP" @default.
- NCIT_C104746 NCIT_P322 "GDC" @default.
- NCIT_C104746 NCIT_P329 "746194" @default.
- NCIT_C104746 NCIT_P330 "746194" @default.
- NCIT_C104746 NCIT_P375 "IGF-1R Inhibitor PL225B" @default.
- NCIT_C104746 NCIT_P399 "746194" @default.
- NCIT_C104746 normalizedInformationContent "100" @default.
- NCIT_C104746 referenceCount "1" @default.
- NCIT_C104746 hasExactSynonym "IGF-1R Inhibitor PL225B" @default.
- NCIT_C104746 hasExactSynonym "PL225B" @default.
- NCIT_C104746 inSubset NCIT_C116977 @default.
- NCIT_C104746 inSubset NCIT_C116978 @default.
- NCIT_C104746 inSubset NCIT_C128784 @default.
- NCIT_C104746 inSubset NCIT_C157711 @default.
- NCIT_C104746 inSubset NCIT_C157712 @default.
- NCIT_C104746 inSubset NCIT_C176424 @default.
- NCIT_C104746 inSubset NCIT_C177537 @default.
- NCIT_C104746 type Class @default.
- NCIT_C104746 isDefinedBy ncit.owl @default.
- NCIT_C104746 label "IGF-1R Inhibitor PL225B" @default.
- NCIT_C104746 subClassOf NCIT_C104746 @default.
- NCIT_C104746 subClassOf NCIT_C129824 @default.
- NCIT_C104746 subClassOf NCIT_C129825 @default.
- NCIT_C104746 subClassOf NCIT_C1404 @default.
- NCIT_C104746 subClassOf NCIT_C1908 @default.
- NCIT_C104746 subClassOf NCIT_C1909 @default.
- NCIT_C104746 subClassOf NCIT_C1967 @default.
- NCIT_C104746 subClassOf NCIT_C2189 @default.
- NCIT_C104746 subClassOf NCIT_C274 @default.
- NCIT_C104746 subClassOf NCIT_C471 @default.