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- NCIT_C105087 IAO_0000115 "Sterol regulatory element-binding protein 1 (1147 aa, ~122 kDa) is encoded by the human SREBF1 gene. This protein is involved in both transcriptional activation and cholesterol homeostasis." @default.
- NCIT_C105087 NCIT_NHC0 "C105087" @default.
- NCIT_C105087 NCIT_P100 "184756" @default.
- NCIT_C105087 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C105087 NCIT_P107 "Sterol Regulatory Element-Binding Protein 1" @default.
- NCIT_C105087 NCIT_P108 "Sterol Regulatory Element-Binding Protein 1" @default.
- NCIT_C105087 NCIT_P207 "C1528373" @default.
- NCIT_C105087 NCIT_P322 "CTRP" @default.
- NCIT_C105087 NCIT_P93 "P36956" @default.
- NCIT_C105087 NCIT_P98 "Sterol regulatory element-binding protein 1 binds to both the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') and the E-box motif (5'-ATCACGTGA-3'). (UniProt)" @default.
- NCIT_C105087 NCIT_P98 "The sterol regulatory element-binding protein 1 is complexed with sterol regulatory element-binding protein cleavage-activating protein in the ER. When cholesterol levels are low, the complex is exported to the Golgi complex where sterol regulatory element-binding protein 1 is cleaved sequentially by site-1 and site-2 proteases. The first cleavage the by site-1 protease occurs within the luminal loop, the second cleavage by the site-2 protease occurs within the first transmembrane domain and releases the transcription factor from the Golgi membrane. After site-2 cleavage, sterol regulatory element-binding protein 1 can be imported into the nucleus where it can activate gene transcription. (UniProt)" @default.
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- NCIT_C105087 hasExactSynonym "Class D Basic Helix-Loop-Helix Protein 1" @default.
- NCIT_C105087 hasExactSynonym "SREBF1" @default.
- NCIT_C105087 hasExactSynonym "SREBP-1" @default.
- NCIT_C105087 hasExactSynonym "Sterol Regulatory Element-Binding Protein 1" @default.
- NCIT_C105087 hasExactSynonym "Sterol Regulatory Element-Binding Transcription Factor 1" @default.
- NCIT_C105087 hasExactSynonym "bHLHd1" @default.
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- NCIT_C105087 type Class @default.
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- NCIT_C105087 label "Sterol Regulatory Element-Binding Protein 1" @default.
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