Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C105150> ?p ?o ?g. }
Showing items 1 to 48 of
48
with 100 items per page.
- NCIT_C105150 IAO_0000115 "An immunoconjugate consisting of an anti-CD19 monoclonal antibody conjugated to the auristatin derivative monomethyl auristatin F (MMAF), with potential antineoplastic activity. Upon administration of denintuzumab mafodotin, the antibody moiety targets the cell surface antigen CD19, found on a number of B-cell-derived cancers. Upon antibody/antigen binding and internalization, the immunoconjugate releases MMAF, which binds to tubulin and inhibits its polymerization. Inhibition of tubulin polymerization may result in G2/M phase arrest and tumor cell apoptosis. This causes inhibition of cell growth of CD19-expressing tumor cells. CD19, a B-cell antigen, is overexpressed by a variety of different cancer cell types." @default.
- NCIT_C105150 NCIT_A32 NCIT_C1909 @default.
- NCIT_C105150 NCIT_A7 NCIT_C38894 @default.
- NCIT_C105150 NCIT_NHC0 "C105150" @default.
- NCIT_C105150 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C105150 NCIT_P107 "Denintuzumab Mafodotin" @default.
- NCIT_C105150 NCIT_P108 "Denintuzumab Mafodotin" @default.
- NCIT_C105150 NCIT_P208 "CL446112" @default.
- NCIT_C105150 NCIT_P210 "1399672-02-6" @default.
- NCIT_C105150 NCIT_P319 "H5324S1M7H" @default.
- NCIT_C105150 NCIT_P322 "CTRP" @default.
- NCIT_C105150 NCIT_P322 "FDA" @default.
- NCIT_C105150 NCIT_P322 "GDC" @default.
- NCIT_C105150 NCIT_P329 "746594" @default.
- NCIT_C105150 NCIT_P330 "746594" @default.
- NCIT_C105150 NCIT_P375 "Denintuzumab Mafodotin" @default.
- NCIT_C105150 NCIT_P399 "746594" @default.
- NCIT_C105150 normalizedInformationContent "100" @default.
- NCIT_C105150 referenceCount "1" @default.
- NCIT_C105150 hasExactSynonym "ADC SGN-19A" @default.
- NCIT_C105150 hasExactSynonym "DENINTUZUMAB MAFODOTIN" @default.
- NCIT_C105150 hasExactSynonym "Denintuzumab Mafodotin" @default.
- NCIT_C105150 hasExactSynonym "Immunoglobulin G1-kappa Auristatin F Conjugate, Anti-(homosapiens CD19 (B Lymphocyte Surface Antigen B4, leu-12)), Humanized Monoclonal Antibody" @default.
- NCIT_C105150 hasExactSynonym "SGN-19A" @default.
- NCIT_C105150 hasExactSynonym "SGN-CD19A" @default.
- NCIT_C105150 inSubset NCIT_C116977 @default.
- NCIT_C105150 inSubset NCIT_C116978 @default.
- NCIT_C105150 inSubset NCIT_C128784 @default.
- NCIT_C105150 inSubset NCIT_C157711 @default.
- NCIT_C105150 inSubset NCIT_C157712 @default.
- NCIT_C105150 inSubset NCIT_C176424 @default.
- NCIT_C105150 inSubset NCIT_C177537 @default.
- NCIT_C105150 inSubset NCIT_C63923 @default.
- NCIT_C105150 type Class @default.
- NCIT_C105150 isDefinedBy ncit.owl @default.
- NCIT_C105150 label "Denintuzumab Mafodotin" @default.
- NCIT_C105150 subClassOf NCIT_C105150 @default.
- NCIT_C105150 subClassOf NCIT_C129821 @default.
- NCIT_C105150 subClassOf NCIT_C129823 @default.
- NCIT_C105150 subClassOf NCIT_C1512 @default.
- NCIT_C105150 subClassOf NCIT_C163758 @default.
- NCIT_C105150 subClassOf NCIT_C1908 @default.
- NCIT_C105150 subClassOf NCIT_C1909 @default.
- NCIT_C105150 subClassOf NCIT_C198634 @default.
- NCIT_C105150 subClassOf NCIT_C198859 @default.
- NCIT_C105150 subClassOf NCIT_C274 @default.
- NCIT_C105150 subClassOf NCIT_C307 @default.
- NCIT_C105150 subClassOf NCIT_C308 @default.