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- NCIT_C105399 IAO_0000115 "An orally available inhibitor of monocarboxylate transporter 1 (MCT1), with potential antineoplastic activity. Upon oral administration, MCT1 inhibitor AZD3965 binds to MCT1 and prevents the transport of lactate into and out of the cell. This leads to an accumulation of lactate, intracellular acidification, and eventually cancer cell death. MCT1, a protein overexpressed on tumor cells, is responsible for the transport of monocarboxylates across the cell membrane and plays a key role in cell metabolism." @default.
- NCIT_C105399 NCIT_A32 NCIT_C1909 @default.
- NCIT_C105399 NCIT_NHC0 "C105399" @default.
- NCIT_C105399 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C105399 NCIT_P108 "Monocarboxylate Transporter 1 Inhibitor AZD3965" @default.
- NCIT_C105399 NCIT_P207 "C3642150" @default.
- NCIT_C105399 NCIT_P210 "1448671-31-5" @default.
- NCIT_C105399 NCIT_P319 "39OM5Y4K2F" @default.
- NCIT_C105399 NCIT_P322 "FDA" @default.
- NCIT_C105399 NCIT_P322 "GDC" @default.
- NCIT_C105399 NCIT_P329 "746809" @default.
- NCIT_C105399 NCIT_P330 "746809" @default.
- NCIT_C105399 NCIT_P375 "Monocarboxylate Transporter 1 Inhibitor AZD3965" @default.
- NCIT_C105399 NCIT_P399 "746809" @default.
- NCIT_C105399 normalizedInformationContent "100" @default.
- NCIT_C105399 referenceCount "1" @default.
- NCIT_C105399 hasExactSynonym "AZD-3965" @default.
- NCIT_C105399 hasExactSynonym "AZD3965" @default.
- NCIT_C105399 hasExactSynonym "MCT1 Inhibitor AZD3965" @default.
- NCIT_C105399 hasExactSynonym "Monocarboxylate Transporter 1 Inhibitor AZD3965" @default.
- NCIT_C105399 inSubset NCIT_C128784 @default.
- NCIT_C105399 inSubset NCIT_C157711 @default.
- NCIT_C105399 inSubset NCIT_C157712 @default.
- NCIT_C105399 inSubset NCIT_C176424 @default.
- NCIT_C105399 inSubset NCIT_C177537 @default.
- NCIT_C105399 inSubset NCIT_C63923 @default.
- NCIT_C105399 type Class @default.
- NCIT_C105399 isDefinedBy ncit.owl @default.
- NCIT_C105399 label "Monocarboxylate Transporter 1 Inhibitor AZD3965" @default.
- NCIT_C105399 subClassOf NCIT_C105399 @default.
- NCIT_C105399 subClassOf NCIT_C129824 @default.
- NCIT_C105399 subClassOf NCIT_C1908 @default.
- NCIT_C105399 subClassOf NCIT_C1909 @default.
- NCIT_C105399 subClassOf NCIT_C2189 @default.
- NCIT_C105399 subClassOf NCIT_C274 @default.