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- NCIT_C105401 IAO_0000115 "An orally bioavailable, synthetic analog of the fatty acid oleic acid, with potential antitumor activity. Upon administration,idroxioleic acid activates sphingomyelin synthase (SMS), thereby increasing the concentration of sphingomyelin (SM) and diacylglycerol (DAG) in the tumor cell membrane and decreasing membrane levels of phosphatidylethanolamine (PE) and phosphatidylcholine (PC). This restores the normal, healthy levels and ratios of membrane lipids. By restoring normal membrane lipid structure and composition, this agent inhibits membrane-protein associated signaling and the aberrant activity of signaling pathways in certain tumor cells, including the Ras/MAPK and PI3K/AKt pathways. This inhibits tumor cell proliferation, induces tumor cell differentiation, and eventually can cause cell death." @default.
- NCIT_C105401 NCIT_A32 NCIT_C1909 @default.
- NCIT_C105401 NCIT_NHC0 "C105401" @default.
- NCIT_C105401 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C105401 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C105401 NCIT_P107 "Idroxioleic Acid" @default.
- NCIT_C105401 NCIT_P108 "Idroxioleic Acid" @default.
- NCIT_C105401 NCIT_P207 "C1566317" @default.
- NCIT_C105401 NCIT_P210 "56472-29-8" @default.
- NCIT_C105401 NCIT_P319 "OSV3KVO1BT" @default.
- NCIT_C105401 NCIT_P322 "CTRP" @default.
- NCIT_C105401 NCIT_P322 "FDA" @default.
- NCIT_C105401 NCIT_P322 "GDC" @default.
- NCIT_C105401 NCIT_P329 "746793" @default.
- NCIT_C105401 NCIT_P330 "746793" @default.
- NCIT_C105401 NCIT_P375 "2-Hydroxyoleic Acid" @default.
- NCIT_C105401 NCIT_P399 "746793" @default.
- NCIT_C105401 normalizedInformationContent "100" @default.
- NCIT_C105401 referenceCount "1" @default.
- NCIT_C105401 hasExactSynonym "2-Hydroxyoleic Acid" @default.
- NCIT_C105401 hasExactSynonym "2-OHOA" @default.
- NCIT_C105401 hasExactSynonym "2OHOA" @default.
- NCIT_C105401 hasExactSynonym "IDROXIOLEIC ACID" @default.
- NCIT_C105401 hasExactSynonym "Idroxioleic Acid" @default.
- NCIT_C105401 hasExactSynonym "LAM 561" @default.
- NCIT_C105401 hasExactSynonym "LAM-561" @default.
- NCIT_C105401 hasExactSynonym "LAM561" @default.
- NCIT_C105401 hasExactSynonym "Minerval" @default.
- NCIT_C105401 hasExactSynonym "NFX88" @default.
- NCIT_C105401 hasExactSynonym "SML-0256" @default.
- NCIT_C105401 inSubset NCIT_C116977 @default.
- NCIT_C105401 inSubset NCIT_C116978 @default.
- NCIT_C105401 inSubset NCIT_C128784 @default.
- NCIT_C105401 inSubset NCIT_C157711 @default.
- NCIT_C105401 inSubset NCIT_C157712 @default.
- NCIT_C105401 inSubset NCIT_C176424 @default.
- NCIT_C105401 inSubset NCIT_C177537 @default.
- NCIT_C105401 inSubset NCIT_C63923 @default.
- NCIT_C105401 type Class @default.
- NCIT_C105401 isDefinedBy ncit.owl @default.
- NCIT_C105401 label "Idroxioleic Acid" @default.
- NCIT_C105401 subClassOf NCIT_C105401 @default.
- NCIT_C105401 subClassOf NCIT_C1908 @default.
- NCIT_C105401 subClassOf NCIT_C1909 @default.
- NCIT_C105401 subClassOf NCIT_C2189 @default.
- NCIT_C105401 subClassOf NCIT_C274 @default.