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- NCIT_C105403 IAO_0000115 "A radioimmunoconjugate, which consists of a monoclonal antibody against the cell-surface antigen CD37 covalently linked, via the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA), to the beta-emitting radioisotope lutetium Lu 177, with potential antineoplastic activity. The antibody moiety of lutetium Lu 177 DOTA-tetulomab binds to CD37 on tumor B-cells. Upon internalization, the radioisotope moiety delivers a cytotoxic dose of beta radiation to CD37-expressing tumor cells. CD37, a transmembrane glycoprotein, is overexpressed in B-cell malignancies." @default.
- NCIT_C105403 NCIT_A32 NCIT_C1909 @default.
- NCIT_C105403 NCIT_A7 NCIT_C102769 @default.
- NCIT_C105403 NCIT_NHC0 "C105403" @default.
- NCIT_C105403 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C105403 NCIT_P107 "Lutetium Lu 177 DOTA-Tetulomab" @default.
- NCIT_C105403 NCIT_P108 "Lutetium Lu 177 DOTA-Tetulomab" @default.
- NCIT_C105403 NCIT_P207 "C3659253" @default.
- NCIT_C105403 NCIT_P319 "CPW7BR9UY7" @default.
- NCIT_C105403 NCIT_P322 "CTRP" @default.
- NCIT_C105403 NCIT_P322 "FDA" @default.
- NCIT_C105403 NCIT_P322 "GDC" @default.
- NCIT_C105403 NCIT_P329 "746917" @default.
- NCIT_C105403 NCIT_P330 "746917" @default.
- NCIT_C105403 NCIT_P375 "Lutetium Lu 177 DOTA-Tetulomab" @default.
- NCIT_C105403 NCIT_P399 "746917" @default.
- NCIT_C105403 normalizedInformationContent "100" @default.
- NCIT_C105403 referenceCount "1" @default.
- NCIT_C105403 hasExactSynonym "177Lu-DOTA-HH1" @default.
- NCIT_C105403 hasExactSynonym "177Lu-Dota-Tetulomab" @default.
- NCIT_C105403 hasExactSynonym "177Lu-HH1" @default.
- NCIT_C105403 hasExactSynonym "Lutetium Lu 177 DOTA-Tetulomab" @default.
- NCIT_C105403 hasExactSynonym "TETULOMAB TETRAXETAN LU-177" @default.
- NCIT_C105403 inSubset NCIT_C116977 @default.
- NCIT_C105403 inSubset NCIT_C116978 @default.
- NCIT_C105403 inSubset NCIT_C128784 @default.
- NCIT_C105403 inSubset NCIT_C157711 @default.
- NCIT_C105403 inSubset NCIT_C157712 @default.
- NCIT_C105403 inSubset NCIT_C176424 @default.
- NCIT_C105403 inSubset NCIT_C177537 @default.
- NCIT_C105403 inSubset NCIT_C63923 @default.
- NCIT_C105403 type Class @default.
- NCIT_C105403 isDefinedBy ncit.owl @default.
- NCIT_C105403 label "Lutetium Lu 177 DOTA-Tetulomab" @default.
- NCIT_C105403 subClassOf NCIT_C105403 @default.
- NCIT_C105403 subClassOf NCIT_C129819 @default.
- NCIT_C105403 subClassOf NCIT_C1446 @default.
- NCIT_C105403 subClassOf NCIT_C1908 @default.
- NCIT_C105403 subClassOf NCIT_C1909 @default.
- NCIT_C105403 subClassOf NCIT_C2124 @default.
- NCIT_C105403 subClassOf NCIT_C274 @default.