Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C105804> ?p ?o ?g. }
Showing items 1 to 41 of
41
with 100 items per page.
- NCIT_C105804 IAO_0000115 "The tosylate salt form of PLX7486, a selective inhibitor of the receptor tyrosine kinases colony-stimulating factor-1 receptor (CSF1R; fms) and neurotrophic tyrosine kinase receptor types 1, 2 and 3 (TrkA, TrkB, and TrkC, respectively) with potential antineoplastic activity. Upon administration, PLX7486 binds to and inhibits the activity of these tyrosine kinases. This inhibits Fms and Trk-mediated signaling transduction pathways that are upregulated in certain cancer cell types. This may eventually halt tumor cell proliferation in Fms and TrkA, TrkB, and/or TrkC-overexpressing tumor cells. Fms and TrkA, TrkB, and TrkC are receptor tyrosine kinases that are upregulated or mutated in a variety of tumors and promote tumor cell proliferation and survival." @default.
- NCIT_C105804 NCIT_A32 NCIT_C1909 @default.
- NCIT_C105804 NCIT_A7 NCIT_C17392 @default.
- NCIT_C105804 NCIT_A7 NCIT_C28558 @default.
- NCIT_C105804 NCIT_A7 NCIT_C33983 @default.
- NCIT_C105804 NCIT_A7 NCIT_C33984 @default.
- NCIT_C105804 NCIT_NHC0 "C105804" @default.
- NCIT_C105804 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C105804 NCIT_P107 "Fms/Trk Tyrosine Kinase Inhibitor PLX7486 Tosylate" @default.
- NCIT_C105804 NCIT_P108 "Fms/Trk Tyrosine Kinase Inhibitor PLX7486 Tosylate" @default.
- NCIT_C105804 NCIT_P207 "C3830093" @default.
- NCIT_C105804 NCIT_P322 "CTRP" @default.
- NCIT_C105804 NCIT_P322 "GDC" @default.
- NCIT_C105804 NCIT_P329 "747694" @default.
- NCIT_C105804 NCIT_P330 "747694" @default.
- NCIT_C105804 NCIT_P375 "Fms/Trk Tyrosine Kinase Inhibitor PLX7486 Tosylate" @default.
- NCIT_C105804 NCIT_P399 "747694" @default.
- NCIT_C105804 normalizedInformationContent "100" @default.
- NCIT_C105804 referenceCount "1" @default.
- NCIT_C105804 hasExactSynonym "Fms/Trk Tyrosine Kinase Inhibitor PLX7486 Tosylate" @default.
- NCIT_C105804 hasExactSynonym "PLX7486-TsOH" @default.
- NCIT_C105804 inSubset NCIT_C116977 @default.
- NCIT_C105804 inSubset NCIT_C116978 @default.
- NCIT_C105804 inSubset NCIT_C128784 @default.
- NCIT_C105804 inSubset NCIT_C157711 @default.
- NCIT_C105804 inSubset NCIT_C157712 @default.
- NCIT_C105804 inSubset NCIT_C176424 @default.
- NCIT_C105804 inSubset NCIT_C177537 @default.
- NCIT_C105804 type Class @default.
- NCIT_C105804 isDefinedBy ncit.owl @default.
- NCIT_C105804 label "Fms/Trk Tyrosine Kinase Inhibitor PLX7486 Tosylate" @default.
- NCIT_C105804 subClassOf NCIT_C105804 @default.
- NCIT_C105804 subClassOf NCIT_C129824 @default.
- NCIT_C105804 subClassOf NCIT_C129825 @default.
- NCIT_C105804 subClassOf NCIT_C1404 @default.
- NCIT_C105804 subClassOf NCIT_C1908 @default.
- NCIT_C105804 subClassOf NCIT_C1909 @default.
- NCIT_C105804 subClassOf NCIT_C1967 @default.
- NCIT_C105804 subClassOf NCIT_C2189 @default.
- NCIT_C105804 subClassOf NCIT_C274 @default.
- NCIT_C105804 subClassOf NCIT_C471 @default.