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- NCIT_C105805 IAO_0000115 "A low-fucosylated, humanized, IgG1 isotype, monoclonal antibody directed against the B-cell-specific membrane protein CD19 with potential immunostimulating and antineoplastic activities. Anti-CD19 monoclonal antibody DI-B4 binds to CD19, which may result in a strong antibody-dependent cellular cytotoxicity (ADCC) directed at CD19-expressing B-cells but with minimal complement dependent cytotoxicity. DI-B4 contains low levels of fucose, which contributes to its enhanced ADCC activity. CD19 is a B-cell specific membrane antigen that is widely expressed during B-cell development and in all B-cell lineage malignancies." @default.
- NCIT_C105805 NCIT_A32 NCIT_C1909 @default.
- NCIT_C105805 NCIT_NHC0 "C105805" @default.
- NCIT_C105805 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C105805 NCIT_P108 "Anti-CD19 Monoclonal Antibody DI-B4" @default.
- NCIT_C105805 NCIT_P208 "CL447157" @default.
- NCIT_C105805 NCIT_P322 "GDC" @default.
- NCIT_C105805 NCIT_P329 "747738" @default.
- NCIT_C105805 NCIT_P330 "747738" @default.
- NCIT_C105805 NCIT_P375 "Anti-CD19 Monoclonal Antibody DI-B4" @default.
- NCIT_C105805 NCIT_P399 "747738" @default.
- NCIT_C105805 NCIT_R124 NCIT_C17710 @default.
- NCIT_C105805 NCIT_R124 NCIT_C17828 @default.
- NCIT_C105805 NCIT_R124 NCIT_C18219 @default.
- NCIT_C105805 NCIT_R124 NCIT_C19986 @default.
- NCIT_C105805 NCIT_R124 NCIT_C40474 @default.
- NCIT_C105805 normalizedInformationContent "100" @default.
- NCIT_C105805 referenceCount "1" @default.
- NCIT_C105805 hasExactSynonym "Anti-CD19 Monoclonal Antibody DI-B4" @default.
- NCIT_C105805 hasExactSynonym "DI-B4" @default.
- NCIT_C105805 hasExactSynonym "anti-CD19 MoAb DI-B4" @default.
- NCIT_C105805 inSubset NCIT_C128784 @default.
- NCIT_C105805 inSubset NCIT_C157711 @default.
- NCIT_C105805 inSubset NCIT_C157712 @default.
- NCIT_C105805 inSubset NCIT_C176424 @default.
- NCIT_C105805 inSubset NCIT_C177537 @default.
- NCIT_C105805 type Class @default.
- NCIT_C105805 isDefinedBy ncit.owl @default.
- NCIT_C105805 label "Anti-CD19 Monoclonal Antibody DI-B4" @default.
- NCIT_C105805 subClassOf NCIT_C105805 @default.
- NCIT_C105805 subClassOf NCIT_C112889 @default.
- NCIT_C105805 subClassOf NCIT_C129820 @default.
- NCIT_C105805 subClassOf NCIT_C129821 @default.
- NCIT_C105805 subClassOf NCIT_C129822 @default.
- NCIT_C105805 subClassOf NCIT_C163758 @default.
- NCIT_C105805 subClassOf NCIT_C1908 @default.
- NCIT_C105805 subClassOf NCIT_C1909 @default.
- NCIT_C105805 subClassOf NCIT_C198634 @default.
- NCIT_C105805 subClassOf NCIT_C20401 @default.
- NCIT_C105805 subClassOf NCIT_C274 @default.
- NCIT_C105805 subClassOf NCIT_C307 @default.
- NCIT_C105805 subClassOf NCIT_C308 @default.