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- NCIT_C105809 IAO_0000115 "Autologous dendritic cells (DCs) transduced with a recombinant, replication-defective adenoviral vector expressing the fusion gene granulocyte-macrophage colony-stimulating factor (GM-CSF) and carbonic anhydrase IX (CA-IX or CA9) (GMCA-9), with potential immunomodulating activity. The autologous DCs are transduced ex vivo and express the GMCA-9 fusion protein on the cell surface. Upon intradermal administration of the AdGMCAIX-transduced autologous DCs back into the patient, the DCs activate the immune system to both mount a cytotoxic T lymphocyte-mediated response against tumor cells positive for the CA9 antigen, and generate memory T cells. This may result in decreased tumor growth. CA9, also known as G250, is a renal cell carcinoma (RCC)-associated antigen and a member of the carbonic anhydrase family that contains a human leukocyte antigen (HLA)-A2.1-restricted epitope; it is found in a majority of renal cell carcinomas while absent in most normal tissues. The cytokine GM-CSF enhances the immunogenicity of CA9-based DC vaccines." @default.
- NCIT_C105809 NCIT_A7 NCIT_C104052 @default.
- NCIT_C105809 NCIT_NHC0 "C105809" @default.
- NCIT_C105809 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C105809 NCIT_P107 "AdGMCAIX-transduced Autologous Dendritic Cells" @default.
- NCIT_C105809 NCIT_P108 "AdGMCAIX-transduced Autologous Dendritic Cells" @default.
- NCIT_C105809 NCIT_P208 "CL447161" @default.
- NCIT_C105809 NCIT_P322 "CTRP" @default.
- NCIT_C105809 NCIT_P329 "747871" @default.
- NCIT_C105809 NCIT_P330 "747871" @default.
- NCIT_C105809 NCIT_P399 "747871" @default.
- NCIT_C105809 normalizedInformationContent "100" @default.
- NCIT_C105809 referenceCount "1" @default.
- NCIT_C105809 hasExactSynonym "AdGMCAIX-transduced Autologous Dendritic Cells" @default.
- NCIT_C105809 hasExactSynonym "DC-AdGMCAIX" @default.
- NCIT_C105809 hasExactSynonym "DCs expressing CMCA9 Gene" @default.
- NCIT_C105809 inSubset NCIT_C116977 @default.
- NCIT_C105809 inSubset NCIT_C116978 @default.
- NCIT_C105809 inSubset NCIT_C128784 @default.
- NCIT_C105809 inSubset NCIT_C176424 @default.
- NCIT_C105809 type Class @default.
- NCIT_C105809 isDefinedBy ncit.owl @default.
- NCIT_C105809 label "AdGMCAIX-transduced Autologous Dendritic Cells" @default.
- NCIT_C105809 subClassOf NCIT_C105809 @default.
- NCIT_C105809 subClassOf NCIT_C129820 @default.
- NCIT_C105809 subClassOf NCIT_C129821 @default.
- NCIT_C105809 subClassOf NCIT_C129826 @default.
- NCIT_C105809 subClassOf NCIT_C142078 @default.
- NCIT_C105809 subClassOf NCIT_C1908 @default.
- NCIT_C105809 subClassOf NCIT_C1909 @default.
- NCIT_C105809 subClassOf NCIT_C274 @default.
- NCIT_C105809 subClassOf NCIT_C307 @default.
- NCIT_C105809 subClassOf NCIT_C308 @default.
- NCIT_C105809 subClassOf NCIT_C61199 @default.