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- NCIT_C105811 IAO_0000115 "A human serotype 5, replication-defective, first generation adenoviral vector, with the viral E1a and E3 protein encoding regions deleted, which is engineered to express the herpes simplex virus thymidine kinase (HSV-tk) gene under the transcriptional control of the CMV promoter. This agent, when administered in conjunction with a synthetic acyclic guanosine analogue, possesses potential antineoplastic activity. Upon administration into the peritumoral region after tumor resection, adenoviral vector encoding HSV thymidine kinase is transduced into tumor cells, and HSV-tk is expressed. Tumor cells expressing HSV-tk are sensitive to synthetic acyclic guanosine analogues. Subsequent administration of a synthetic acyclic guanosine analogue, such as valacyclovir (VCV) or ganciclovir (GCV), kills the tumor cells expressing HSV-tk. The release of tumor-associated antigens (TAA) by dying tumor cells may then stimulate an antitumor cytotoxic T lymphocyte (CTL) response, directed aganst any remaining tumor cells." @default.
- NCIT_C105811 NCIT_NHC0 "C105811" @default.
- NCIT_C105811 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C105811 NCIT_P107 "Ad-hCMV-TK" @default.
- NCIT_C105811 NCIT_P108 "Ad-hCMV-TK" @default.
- NCIT_C105811 NCIT_P208 "CL447163" @default.
- NCIT_C105811 NCIT_P322 "CTRP" @default.
- NCIT_C105811 NCIT_P329 "747932" @default.
- NCIT_C105811 NCIT_P330 "747932" @default.
- NCIT_C105811 NCIT_P399 "747932" @default.
- NCIT_C105811 normalizedInformationContent "100" @default.
- NCIT_C105811 referenceCount "1" @default.
- NCIT_C105811 hasExactSynonym "Ad-hCMV-TK" @default.
- NCIT_C105811 inSubset NCIT_C116977 @default.
- NCIT_C105811 inSubset NCIT_C116978 @default.
- NCIT_C105811 inSubset NCIT_C128784 @default.
- NCIT_C105811 inSubset NCIT_C176424 @default.
- NCIT_C105811 type Class @default.
- NCIT_C105811 isDefinedBy ncit.owl @default.
- NCIT_C105811 label "Ad-hCMV-TK" @default.
- NCIT_C105811 subClassOf NCIT_C105811 @default.
- NCIT_C105811 subClassOf NCIT_C1908 @default.
- NCIT_C105811 subClassOf NCIT_C1909 @default.
- NCIT_C105811 subClassOf NCIT_C1962 @default.
- NCIT_C105811 subClassOf NCIT_C307 @default.
- NCIT_C105811 subClassOf NCIT_C61199 @default.